Treating Hallucinations and Delusions Associated With Parkinson’s Disease Psychosis

Shyam C. Panchal; William G. Ondo

doi:10.1007/s11920-018-0869-z

Treating Hallucinations and Delusions Associated With Parkinson’s Disease Psychosis

Shyam C. Panchal, William G. Ondo

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

Purpose of Review: We discuss features of Parkinson’s disease psychosis (PDP) including symptomology and pathophysiology. Treatment options, including non-pharmacologic strategies, dose reduction of offending agents, and the addition of non-dopaminergic antipsychotics, are addressed. The efficacy of second-generation antipsychotics and novel agents is examined. Recent Findings: Pimavanserin, a 5-HT_2A/C receptor inverse agonist with no other receptor activity, has shown efficacy and tolerability and is now FDA approved for PDP treatment. Research into novel targets is ongoing. Summary: PDP is a morbid complication of Parkinson’s disease with complex incompletely understood mechanisms. Treatment is directed towards mitigation of psychosis without worsening of motor features.

Original language	English (US)
Article number	3
Journal	Current Psychiatry Reports
Volume	20
Issue number	1
DOIs	https://doi.org/10.1007/s11920-018-0869-z
State	Published - Jan 1 2018

Keywords

Antipsychotic
Delusions
Hallucinations
Parkinson’s disease
Pimavanserin
Psychosis

ASJC Scopus subject areas

Psychiatry and Mental health

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10.1007/s11920-018-0869-z

Cite this

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title = "Treating Hallucinations and Delusions Associated With Parkinson{\textquoteright}s Disease Psychosis",

abstract = "Purpose of Review: We discuss features of Parkinson{\textquoteright}s disease psychosis (PDP) including symptomology and pathophysiology. Treatment options, including non-pharmacologic strategies, dose reduction of offending agents, and the addition of non-dopaminergic antipsychotics, are addressed. The efficacy of second-generation antipsychotics and novel agents is examined. Recent Findings: Pimavanserin, a 5-HT2A/C receptor inverse agonist with no other receptor activity, has shown efficacy and tolerability and is now FDA approved for PDP treatment. Research into novel targets is ongoing. Summary: PDP is a morbid complication of Parkinson{\textquoteright}s disease with complex incompletely understood mechanisms. Treatment is directed towards mitigation of psychosis without worsening of motor features.",

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doi = "10.1007/s11920-018-0869-z",

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AU - Ondo, William G.

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N2 - Purpose of Review: We discuss features of Parkinson’s disease psychosis (PDP) including symptomology and pathophysiology. Treatment options, including non-pharmacologic strategies, dose reduction of offending agents, and the addition of non-dopaminergic antipsychotics, are addressed. The efficacy of second-generation antipsychotics and novel agents is examined. Recent Findings: Pimavanserin, a 5-HT2A/C receptor inverse agonist with no other receptor activity, has shown efficacy and tolerability and is now FDA approved for PDP treatment. Research into novel targets is ongoing. Summary: PDP is a morbid complication of Parkinson’s disease with complex incompletely understood mechanisms. Treatment is directed towards mitigation of psychosis without worsening of motor features.

AB - Purpose of Review: We discuss features of Parkinson’s disease psychosis (PDP) including symptomology and pathophysiology. Treatment options, including non-pharmacologic strategies, dose reduction of offending agents, and the addition of non-dopaminergic antipsychotics, are addressed. The efficacy of second-generation antipsychotics and novel agents is examined. Recent Findings: Pimavanserin, a 5-HT2A/C receptor inverse agonist with no other receptor activity, has shown efficacy and tolerability and is now FDA approved for PDP treatment. Research into novel targets is ongoing. Summary: PDP is a morbid complication of Parkinson’s disease with complex incompletely understood mechanisms. Treatment is directed towards mitigation of psychosis without worsening of motor features.

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Treating Hallucinations and Delusions Associated With Parkinson’s Disease Psychosis

Abstract

Keywords

ASJC Scopus subject areas

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