Treating fibrosing cholestatic hepatitis C with sofosbuvir and ribavirin: A matched analysis

Sammy Saab, Melissa Jimenez, Sherona Bau, Tyralee Goo, Difan Zhao, Francisco Durazo, Steven Han, Mohammed El Kabany, Fady Kaldas, Myron J. Tong, Ronald W. Busuttil

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Background: Fibrosing cholestatic hepatitis (FCH) is an uncommon but potentially fatal complication of recurrent hepatitis C (HCV) in liver transplant recipients. Methods: We matched the treatment outcomes of 10 liver transplant recipients who developed FCH with those of 10 recipients with recurrent HCV without FCH treated with sofosbuvir and ribavirin. Results: Baseline mean alanine transaminase, aspartate transaminase, alkaline phosphatase, and total bilirubin were 186 U/L, 197 U/L, 243 U/L, and 6.7 mg/dL, respectively, in the FCH recipients and 82 U/L, 60 U/L, 110 U/L, and 0.99 mg/dL, respectively, in non-FCH recipients. The sustained viral response in FCH and non-FCH recipients was 40% and 80%, respectively. One-yr patient and graft survival rates were 90% and 80%, respectively, in FCH recipients, and 100% in non-FCH recipients. Seven FCH and six non-FCH recipients were treated for anemia with blood transfusion and/or erythropoietin growth factors. Conclusion: Our results suggest that the use of sofosbuvir and ribavirin is effective and tolerable in liver transplant recipients treated for recurrent FCH. There is a trend of lower sustained viral response, patient survival, and graft survival in the FCH recipients.

Original languageEnglish (US)
Pages (from-to)813-819
Number of pages7
JournalClinical Transplantation
Issue number9
StatePublished - Sep 1 2015


  • Antiviral therapy
  • Fibrosing cholestatic hepatitis
  • Hepatitis C
  • Liver transplant
  • Patient survival

ASJC Scopus subject areas

  • Transplantation


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