Trauma exposure and sleep: Using a rodent model to understand sleep function in PTSD

William M. Vanderheyden, Gina R. Poe, Israel Liberzon

Research output: Contribution to journalReview article

25 Scopus citations

Abstract

Post-traumatic stress disorder (PTSD) is characterized by intrusive memories of a traumatic event, avoidance behavior related to cues of the trauma, emotional numbing, and hyper-arousal. Sleep abnormalities and nightmares are core symptoms of this disorder. In this review, we propose a model which implicates abnormal activity in the locus coeruleus (LC), an important modifier of sleep-wake regulation, as the source of sleep abnormalities and memory abnormalities seen in PTSD. Abnormal LC activity may be playing a key role in symptom formation in PTSD via sleep dysregulation and suppression of hippocampal bidirectional plasticity.

Original languageEnglish (US)
Pages (from-to)1575-1584
Number of pages10
JournalExperimental Brain Research
Volume232
Issue number5
DOIs
StatePublished - Jan 1 2014

Keywords

  • Locus coeruleus
  • PTSD
  • Sleep

ASJC Scopus subject areas

  • Neuroscience(all)

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