TY - JOUR
T1 - Transurethral collagen injections for male intrinsic sphincter deficiency
T2 - The University of Texas-Houston experience
AU - Westney, Ouida L.
AU - Bevan-Thomas, Richard
AU - Palmer, J. Lynn
AU - Cespedes, R. Duane
AU - McGuire, Edward J.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2005/9
Y1 - 2005/9
N2 - Purpose: Injectable agents are used to increase urethral coaptation for the treatment of intrinsic sphincter deficiency. We evaluated the long-term results and complications of transurethral collagen injections in males. Materials and Methods: We reviewed the charts of 322 men (mean age 67.2 years, range 40 to 91) with intrinsic sphincter deficiency after therapy for prostate carcinoma (307) or benign prostatic hyperplasia (15) who received transurethral collagen injections. The analysis included types and combinations of treatment for prostate cancer or benign prostatic hyperplasia, pre-procedure voiding symptoms, total collagen received, maximal percentage improvement and durability of effect. Results: The mean length of followup was 40.1 (±13.2) months. Overall, the mean number of injections was 4.37 (±2.09). Mean percent improvement after a series of injections was 44.59 (±38.26). Mean pad use before and after injection was statistically different (5.15 vs 2.98, p=0.0001). Mean duration of response was 6.3 (±8.14) months. In those who achieved complete continence (17%), the mean duration of response was 11.1 (±8.87) months. Within this group the mean number of injections and ml of collagen injected were 3.83 and 29.27, respectively. Five patients (1.5%) complained of a quantitative increase in leakage after their series of collagen injections. Conclusions: Transurethral collagen injections are a good option for short-term therapy in men with post-prostatectomy incontinence. The mean number of injections to achieve a plateau is 3 to 4, regardless of initial severity of incontinence. Those in the radical prostatectomy only treatment group are statistically more likely to achieve continence than all other treatment groups.
AB - Purpose: Injectable agents are used to increase urethral coaptation for the treatment of intrinsic sphincter deficiency. We evaluated the long-term results and complications of transurethral collagen injections in males. Materials and Methods: We reviewed the charts of 322 men (mean age 67.2 years, range 40 to 91) with intrinsic sphincter deficiency after therapy for prostate carcinoma (307) or benign prostatic hyperplasia (15) who received transurethral collagen injections. The analysis included types and combinations of treatment for prostate cancer or benign prostatic hyperplasia, pre-procedure voiding symptoms, total collagen received, maximal percentage improvement and durability of effect. Results: The mean length of followup was 40.1 (±13.2) months. Overall, the mean number of injections was 4.37 (±2.09). Mean percent improvement after a series of injections was 44.59 (±38.26). Mean pad use before and after injection was statistically different (5.15 vs 2.98, p=0.0001). Mean duration of response was 6.3 (±8.14) months. In those who achieved complete continence (17%), the mean duration of response was 11.1 (±8.87) months. Within this group the mean number of injections and ml of collagen injected were 3.83 and 29.27, respectively. Five patients (1.5%) complained of a quantitative increase in leakage after their series of collagen injections. Conclusions: Transurethral collagen injections are a good option for short-term therapy in men with post-prostatectomy incontinence. The mean number of injections to achieve a plateau is 3 to 4, regardless of initial severity of incontinence. Those in the radical prostatectomy only treatment group are statistically more likely to achieve continence than all other treatment groups.
KW - Collagen
KW - Injections
KW - Prostatectomy
KW - Urinary incontinence
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U2 - 10.1097/01.ju.0000170237.72750.64
DO - 10.1097/01.ju.0000170237.72750.64
M3 - Article
C2 - 16094021
AN - SCOPUS:23744481171
VL - 174
SP - 994
EP - 997
JO - Journal of Urology
JF - Journal of Urology
SN - 0022-5347
IS - 3
ER -