@article{08412897309b4855aa1646e0ac7877e0,
title = "Transposon mutagenesis identifies genes that cooperate with mutant Pten in breast cancer progression",
abstract = "Triple-negative breast cancer (TNBC) has the worst prognosis of any breast cancer subtype. To better understand the genetic forces driving TNBC, we performed a transposon mutagenesis screen in a phosphatase and tensin homolog (Pten) mutant mice and identified 12 candidate trunk drivers and a much larger number of progression genes. Validation studies identified eight TNBC tumor suppressor genes, including the GATA-like transcriptional repressor TRPS1. Down-regulation of TRPS1 in TNBC cells promoted epithelial-to-mesenchymal transition (EMT) by deregulating multiple EMT pathway genes, in addition to increasing the expression of SERPINE1 and SERPINB2 and the subsequent migration, invasion, and metastasis of tumor cells. Transposon mutagenesis has thus provided a better understanding of the genetic forces driving TNBC and discovered genes with potential clinical importance in TNBC.",
keywords = "Breast cancer, Metastasis, Sleeping Beauty, TRPS1, Tumor suppressors",
author = "Roberto Rangel and Lee, {Song Choon} and Ban, {Kenneth Hon Kim} and Liliana Guzman-Rojas and Mann, {Michael B.} and Newberg, {Justin Y.} and Takahiro Kodama and McNoe, {Leslie A.} and Luxmanan Selvanesan and Ward, {Jerrold M.} and Rust, {Alistair G.} and Chin, {Kuan Yew} and Black, {Michael A.} and Jenkins, {Nancy A.} and Copeland, {Neal G.}",
note = "Funding Information: We thank K. Rogers, S. Rogers and the Institute of Molecular and Cell Biology histopathology core for performing histological analysis, and P. Cheok, N. Lim, D. Chen, C. Wee, E. Freiter, and H. Lee for monitoring mice and animal technical assistance. The Biomedical Research Council, Agency for Science, Technology and Research (A-STAR), Singapore, and The Cancer Research Institute of Texas (CIPRIT), supported this research. A.G.R. was supported by the Cancer Research UK and the Wellcome Trust. Both N.G.C. and N.A.J. are CPRIT Scholars in Cancer Research. Publisher Copyright: {\textcopyright} 2016, National Academy of Sciences. All rights reserved.",
year = "2016",
month = nov,
day = "29",
doi = "10.1073/pnas.1613859113",
language = "English (US)",
volume = "113",
pages = "E7749--E7758",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "48",
}