Transport of large molecules in hyaluronic acid-based membranes and solution

Enrica De Rosa; Cristina Borselli; Paolo A. Netti

doi:10.1016/j.memsci.2005.10.020

Transport of large molecules in hyaluronic acid-based membranes and solution

Enrica De Rosa, Cristina Borselli, Paolo A. Netti

Houston Methodist

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The aim of this work was to analyse the hindrance effect of the naturally derived bioactive polymer hyaluronic acid (HA) considered responsible for the interstitium transport regulation. The diffusion coefficient measurements of several macromolecular probes, different for nature and dimension have been performed within HA water solution and HA collagenous gels in order to study the role of HA on the control of macromolecular transport. HA matrices showed less diffusional hindrance then HA water solutions. Moreover, the HA, interpenetrating with the collagen fibres, selectively affected the transport, depending on the HA concentration. These preliminary studies indicate that the biopolymer HA can be employed to design novel biopolymer interpenetrating gels suitable as molecular sieves for membrane permeation and controlled drug delivery.

Original language	English (US)
Pages (from-to)	84-88
Number of pages	5
Journal	Journal of Membrane Science
Volume	273
Issue number	1-2
DOIs	https://doi.org/10.1016/j.memsci.2005.10.020
State	Published - Mar 31 2006

Keywords

Collagen
Hindrance
Hyaluronic acid
Molecular transport
Probes

ASJC Scopus subject areas

Biochemistry
Materials Science(all)
Physical and Theoretical Chemistry
Filtration and Separation

Access to Document

10.1016/j.memsci.2005.10.020

Cite this

@article{746fa73e75114e72ab00e35ea4e348ab,

title = "Transport of large molecules in hyaluronic acid-based membranes and solution",

abstract = "The aim of this work was to analyse the hindrance effect of the naturally derived bioactive polymer hyaluronic acid (HA) considered responsible for the interstitium transport regulation. The diffusion coefficient measurements of several macromolecular probes, different for nature and dimension have been performed within HA water solution and HA collagenous gels in order to study the role of HA on the control of macromolecular transport. HA matrices showed less diffusional hindrance then HA water solutions. Moreover, the HA, interpenetrating with the collagen fibres, selectively affected the transport, depending on the HA concentration. These preliminary studies indicate that the biopolymer HA can be employed to design novel biopolymer interpenetrating gels suitable as molecular sieves for membrane permeation and controlled drug delivery.",

keywords = "Collagen, Hindrance, Hyaluronic acid, Molecular transport, Probes",

author = "{De Rosa}, Enrica and Cristina Borselli and Netti, {Paolo A.}",

year = "2006",

month = mar,

day = "31",

doi = "10.1016/j.memsci.2005.10.020",

language = "English (US)",

volume = "273",

pages = "84--88",

journal = "Journal of Membrane Science",

issn = "0376-7388",

publisher = "Elsevier",

number = "1-2",

}

TY - JOUR

T1 - Transport of large molecules in hyaluronic acid-based membranes and solution

AU - De Rosa, Enrica

AU - Borselli, Cristina

AU - Netti, Paolo A.

PY - 2006/3/31

Y1 - 2006/3/31

N2 - The aim of this work was to analyse the hindrance effect of the naturally derived bioactive polymer hyaluronic acid (HA) considered responsible for the interstitium transport regulation. The diffusion coefficient measurements of several macromolecular probes, different for nature and dimension have been performed within HA water solution and HA collagenous gels in order to study the role of HA on the control of macromolecular transport. HA matrices showed less diffusional hindrance then HA water solutions. Moreover, the HA, interpenetrating with the collagen fibres, selectively affected the transport, depending on the HA concentration. These preliminary studies indicate that the biopolymer HA can be employed to design novel biopolymer interpenetrating gels suitable as molecular sieves for membrane permeation and controlled drug delivery.

AB - The aim of this work was to analyse the hindrance effect of the naturally derived bioactive polymer hyaluronic acid (HA) considered responsible for the interstitium transport regulation. The diffusion coefficient measurements of several macromolecular probes, different for nature and dimension have been performed within HA water solution and HA collagenous gels in order to study the role of HA on the control of macromolecular transport. HA matrices showed less diffusional hindrance then HA water solutions. Moreover, the HA, interpenetrating with the collagen fibres, selectively affected the transport, depending on the HA concentration. These preliminary studies indicate that the biopolymer HA can be employed to design novel biopolymer interpenetrating gels suitable as molecular sieves for membrane permeation and controlled drug delivery.

KW - Collagen

KW - Hindrance

KW - Hyaluronic acid

KW - Molecular transport

KW - Probes

UR - http://www.scopus.com/inward/record.url?scp=32444433905&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=32444433905&partnerID=8YFLogxK

U2 - 10.1016/j.memsci.2005.10.020

DO - 10.1016/j.memsci.2005.10.020

M3 - Article

AN - SCOPUS:32444433905

SN - 0376-7388

VL - 273

SP - 84

EP - 88

JO - Journal of Membrane Science

JF - Journal of Membrane Science

IS - 1-2

ER -

Transport of large molecules in hyaluronic acid-based membranes and solution

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this