Transplantation for acute liver failure: Perioperative management

Randolph H. Steadman, Adriaan Van Rensburg, David J. Kramer

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


PURPOSE OF REVIEW: A number of conditions can lead to acute liver failure. Determining the cause has important prognostic implications that guide decisions regarding the likelihood of spontaneous recovery, or conversely, the need for transplantation. RECENT FINDINGS: Neurological deterioration is associated with intracranial hypertension, which requires meticulous management. The decision to employ invasive intracranial pressure monitoring is controversial because of associated risks and the lack of controlled studies. Recent literature addressing the use of intracranial pressure monitoring is reviewed. SUMMARY: Even tertiary care units that specialize in liver disease treat acute liver failure patients infrequently. Knowledge of the latest guidelines and treatment protocols can lead to improved patient care

Original languageEnglish (US)
Pages (from-to)368-373
Number of pages6
JournalCurrent opinion in organ transplantation
Issue number3
StatePublished - Jun 2010


  • Acute liver failure
  • Cerebral edema
  • Fulminant hepatic failure
  • Intracranial hypertension
  • Liver transplantation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation


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