Transitional Cell Carcinoma Metastatic to Lung, With Dedifferentiation Into Small Cell Undifferentiated Carcinoma

David L. Todd, Rodolfo Laucirica, Mary L. Ostrowski, Richard Brown, Luan Truong

Research output: Contribution to journalArticle

Abstract

Small-cell undifferentiated carcinoma (SCUC) has been increasingly recognized in the urinary tract.1,2,3 Up to 66% of SCUCs in this location are associated with a minor component of a more differentiated carcinoma that most frequently represents transi tional-cell carcinoma (TCC), but adenocarcinoma, squamous-cell carcinoma, spindle- cell carcinoma, and carcinoid carcinoma have all been described. We report a case of low-grade TCC of the urinary tract metastasizing to a distant location and therein dedifferentiating into an SCUC and discuss the clinical and biologic implication of the process of dedifferentiation. Int J Surg Pathol 2(2):157-162, 1994

Original languageEnglish (US)
Pages (from-to)157-162
Number of pages6
JournalInternational Journal of Surgical Pathology
Volume2
Issue number2
DOIs
StatePublished - 1994

Keywords

  • dedif ferentiation
  • small-cell undifferentiated carcinoma
  • transitional cell carcinoma

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

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