Transfusion-Related Acute Lung Injury (TRALI) Following Allogeneic Stem Cell Transplant for Acute Myeloid Leukemia

Siddhartha Ganguly, George Carrum, Frank Nizzi, Helen Heslop, Uday Popat

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Transfusion-related acute lung injury (TRALI) is a serious complication of transfusion characterized by dyspnea, hypoxemia, hypotension, fever, and bilateral pulmonary infiltrates. Although the frequency is estimated at 1/1,120 to 1/5,000 transfusions, few cases have been reported after hematopoietic stem cell transplant. We report a case occurring in an allogeneic transplant recipient who developed acute respiratory distress and bilateral pulmonary infiltrates 2 hr after a platelet transfusion due to the presence of anti granulocyte antibody HNA-3a in the product. As there is a wide differential diagnosis for pulmonary infiltrates developing post transplant, TRALI may be under-recognized and should be considered in this setting.

Original languageEnglish (US)
Pages (from-to)48-51
Number of pages4
JournalAmerican Journal of Hematology
Volume75
Issue number1
DOIs
StatePublished - Jan 2004

Keywords

  • Hematopoietic stem cell transplantation
  • TRALI
  • Transfusion

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Transfusion-Related Acute Lung Injury (TRALI) Following Allogeneic Stem Cell Transplant for Acute Myeloid Leukemia'. Together they form a unique fingerprint.

Cite this