Transforming growth factor-beta localization during mouse prostate morphogenesis and in prostatic growth abnormalities

T. L. Timme, G. Yang, Luan Truong, D. Kadmon, S. H. Park, T. C. Thompson

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Growth and morphogenesis of the prostate involves mesenchymal-epithelial interactions. Transforming growth factor-beta 1 (TGF-β1) is one growth factor that may play a role in these paracrine interactions. We have localized TGF-β1 by molecular and immunohistochemical analysis in the developing mouse prostate. Accumulations of TGF-β1 protein were localized in the mesenchyme surrounding ductules in fetal and neonatal prostate. Previous studies in the mouse prostate reconstitution (MPR) model system have localized accumulations of TGF-β1 to regions of oncogene-induced abnormalities. In surgically excised adult human prostate tissues, localized accumulations of TGF-β1 are associated with prostate cancer and benign prostatic hyperplasia (BPH). Intracellular TGF-β1 was more often associated with stromal cells in BPH and with neoplastic epithelial cells in prostate cancer. The production and accumulation of TGF-β1 appears to involve interactions between mesenchymal and epithelial cells. Further experimental studies may clarify the relationships between TGF-β1 and abnormal prostatic growth.

Original languageEnglish (US)
Pages (from-to)324-328
Number of pages5
JournalWorld Journal of Urology
Volume13
Issue number6
DOIs
StatePublished - Dec 1995

ASJC Scopus subject areas

  • Urology

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