Transforming growth factor-β protein inversely regulates in vivo differentiation of interleukin-17 (IL-17)-producing CD4 + and CD8 + T cells

Ved Prakash Dwivedi, Sultan Tousif, Debapriya Bhattacharya, Durbaka Vijay Raghva Prasad, Luc Van Kaer, Jyoti Das, Gobardhan Das

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

TGF-β is a pleiotropic cytokine that predominantly exerts inhibitory functions in the immune system. Unexpectedly, the in vitro differentiation of both Th17 and Tc17 cells requires TGF-β. However, animals that are impaired in TGF-β signaling (TGF-βRIIDN mice) display multiorgan autoimmune disorders. Here we show that CD4 + T cells from TGF-βRIIDN mice are resistant to Th17 cell differentiation and, paradoxically, that CD8 + T cells from these animals spontaneously acquire an IL-17-producing phenotype. Neutralization of IL-17 or depletion of CD8 + T cells dramatically inhibited inflammation in TGF-βRIIDN mice. Therefore, the absence of TGF-β triggers spontaneous differentiation of IL-17-producing CD8 + T cells, suggesting that the in vivo and in vitro conditions that promote the differentiation of IL-17-producing CD8 + T cells are distinct.

Original languageEnglish (US)
Pages (from-to)2943-2947
Number of pages5
JournalJournal of Biological Chemistry
Volume287
Issue number5
DOIs
StatePublished - Jan 27 2012

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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