Abstract
Graphene represents the ultimate substrate for high-resolution transmission electron microscopy, but the deposition of biological samples on this highly hydrophobic material has until now been a challenge. We present a reliable method for depositing ordered arrays of individual elongated DNA molecules on single-layer graphene substrates for high-resolution electron beam imaging and electron energy loss spectroscopy analysis. This method is a necessary step toward the observation of single elongated DNA molecules with single base spatial resolution to directly read genetic and epigenetic information.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4232-4238 |
| Number of pages | 7 |
| Journal | Nano Letters |
| Volume | 11 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 12 2011 |
Keywords
- DNA
- electronenergy loss spectroscopy
- genetics/epigenetics
- Graphene
- nanopatterning
- transmission electron microscopy
ASJC Scopus subject areas
- Condensed Matter Physics
- Bioengineering
- General Chemistry
- General Materials Science
- Mechanical Engineering
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