Transfer-printing of single dna molecule arrays on graphene for high-resolution electron imaging and analysis

Aline Cerf, Thomas Alava, Robert A. Barton, Harold G. Craighead

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Graphene represents the ultimate substrate for high-resolution transmission electron microscopy, but the deposition of biological samples on this highly hydrophobic material has until now been a challenge. We present a reliable method for depositing ordered arrays of individual elongated DNA molecules on single-layer graphene substrates for high-resolution electron beam imaging and electron energy loss spectroscopy analysis. This method is a necessary step toward the observation of single elongated DNA molecules with single base spatial resolution to directly read genetic and epigenetic information.

Original languageEnglish (US)
Pages (from-to)4232-4238
Number of pages7
JournalNano Letters
Volume11
Issue number10
DOIs
StatePublished - Oct 12 2011

Keywords

  • DNA
  • electronenergy loss spectroscopy
  • genetics/epigenetics
  • Graphene
  • nanopatterning
  • transmission electron microscopy

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanical Engineering

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