Transfer-printing of single dna molecule arrays on graphene for high-resolution electron imaging and analysis

Aline Cerf; Thomas Alava; Robert A. Barton; Harold G. Craighead

doi:10.1021/nl202219w

Transfer-printing of single dna molecule arrays on graphene for high-resolution electron imaging and analysis

Aline Cerf, Thomas Alava, Robert A. Barton, Harold G. Craighead

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Graphene represents the ultimate substrate for high-resolution transmission electron microscopy, but the deposition of biological samples on this highly hydrophobic material has until now been a challenge. We present a reliable method for depositing ordered arrays of individual elongated DNA molecules on single-layer graphene substrates for high-resolution electron beam imaging and electron energy loss spectroscopy analysis. This method is a necessary step toward the observation of single elongated DNA molecules with single base spatial resolution to directly read genetic and epigenetic information.

Original language	English (US)
Pages (from-to)	4232-4238
Number of pages	7
Journal	Nano Letters
Volume	11
Issue number	10
DOIs	https://doi.org/10.1021/nl202219w
State	Published - Oct 12 2011

Keywords

DNA
electronenergy loss spectroscopy
genetics/epigenetics
Graphene
nanopatterning
transmission electron microscopy

ASJC Scopus subject areas

Condensed Matter Physics
Bioengineering
Chemistry(all)
Materials Science(all)
Mechanical Engineering

Access to Document

10.1021/nl202219w

Cite this

@article{0f6d5e60909347bc92cf39e75a5f39e9,

title = "Transfer-printing of single dna molecule arrays on graphene for high-resolution electron imaging and analysis",

abstract = "Graphene represents the ultimate substrate for high-resolution transmission electron microscopy, but the deposition of biological samples on this highly hydrophobic material has until now been a challenge. We present a reliable method for depositing ordered arrays of individual elongated DNA molecules on single-layer graphene substrates for high-resolution electron beam imaging and electron energy loss spectroscopy analysis. This method is a necessary step toward the observation of single elongated DNA molecules with single base spatial resolution to directly read genetic and epigenetic information.",

keywords = "DNA, electronenergy loss spectroscopy, genetics/epigenetics, Graphene, nanopatterning, transmission electron microscopy",

author = "Aline Cerf and Thomas Alava and Barton, {Robert A.} and Craighead, {Harold G.}",

year = "2011",

month = oct,

day = "12",

doi = "10.1021/nl202219w",

language = "English (US)",

volume = "11",

pages = "4232--4238",

journal = "Nano Letters",

issn = "1530-6984",

publisher = "American Chemical Society",

number = "10",

}

TY - JOUR

T1 - Transfer-printing of single dna molecule arrays on graphene for high-resolution electron imaging and analysis

AU - Cerf, Aline

AU - Alava, Thomas

AU - Barton, Robert A.

AU - Craighead, Harold G.

PY - 2011/10/12

Y1 - 2011/10/12

N2 - Graphene represents the ultimate substrate for high-resolution transmission electron microscopy, but the deposition of biological samples on this highly hydrophobic material has until now been a challenge. We present a reliable method for depositing ordered arrays of individual elongated DNA molecules on single-layer graphene substrates for high-resolution electron beam imaging and electron energy loss spectroscopy analysis. This method is a necessary step toward the observation of single elongated DNA molecules with single base spatial resolution to directly read genetic and epigenetic information.

AB - Graphene represents the ultimate substrate for high-resolution transmission electron microscopy, but the deposition of biological samples on this highly hydrophobic material has until now been a challenge. We present a reliable method for depositing ordered arrays of individual elongated DNA molecules on single-layer graphene substrates for high-resolution electron beam imaging and electron energy loss spectroscopy analysis. This method is a necessary step toward the observation of single elongated DNA molecules with single base spatial resolution to directly read genetic and epigenetic information.

KW - DNA

KW - electronenergy loss spectroscopy

KW - genetics/epigenetics

KW - Graphene

KW - nanopatterning

KW - transmission electron microscopy

UR - http://www.scopus.com/inward/record.url?scp=80054033858&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80054033858&partnerID=8YFLogxK

U2 - 10.1021/nl202219w

DO - 10.1021/nl202219w

M3 - Article

C2 - 21919532

AN - SCOPUS:80054033858

SN - 1530-6984

VL - 11

SP - 4232

EP - 4238

JO - Nano Letters

JF - Nano Letters

IS - 10

ER -

Transfer-printing of single dna molecule arrays on graphene for high-resolution electron imaging and analysis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this