Transfer of EBV-specific CTL to prevent EBV lymphoma post bone marrow transplant

Helen Heslop, Margot Perez, Ely Benaim, Richard Rochester, Malcolm Brenner, Cliona M. Rooney

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations

Abstract

EBV-associated lymphoproliferative disorders (EBV-LPD) are a significant problem after hemopoietic stem cell transplantation from unrelated donors or mismatched family members. Risk factors include T-cell depletion, MHC mismatch, and intensity of immunosuppression. New therapeutic strategies involve cellular immunotherapy approaches and both donor T-cells and EBV- specific cytotoxic T lymphocytes (CTLs) have proven to be effective therapies. EBV-specific CTL has also proved to have a major impact on the incidence of this complication when used prophylactically.

Original languageEnglish (US)
Pages (from-to)154-156
Number of pages3
JournalJournal of Clinical Apheresis
Volume14
Issue number3
DOIs
StatePublished - Nov 22 1999

ASJC Scopus subject areas

  • Hematology

Fingerprint

Dive into the research topics of 'Transfer of EBV-specific CTL to prevent EBV lymphoma post bone marrow transplant'. Together they form a unique fingerprint.

Cite this