TRANSFER OF A FUNCTIONING HUMORAL IMMUNE SYSTEM IN TRANSPLANTATION OF T-LYMPHOCYTE-DEPLETED BONE MARROW

J. Z. Wimperis, H. G. Prentice, P. Karayiannis, M. K. Brenner, J. E. Reittie, P. D. Griffiths, A. V. Hoffbrand

Research output: Contribution to journalArticlepeer-review

121 Scopus citations

Abstract

To test the effect of transplantation of T-cell-depleted bone marow on recipient immune function the results of pre-transplantation immunisation with tetanus toxoid and hepatitis-B vaccine were studied in 38 donor-recipient pairs. Immunisation of the donor alone resulted in transfer of an antibody response to the recipient; immunisation of both donor and recipient resulted in potentiation of the antibody response in both magnitude and duration. These findings indicate that donor T-cell-depleted marrow can transfer humoral immunity to the recipient and that appropriate pre-transplant immunisation schedules may be of benefit to the recipient.

Original languageEnglish (US)
Pages (from-to)339-343
Number of pages5
JournalThe Lancet
Volume327
Issue number8477
DOIs
StatePublished - Feb 15 1986

ASJC Scopus subject areas

  • Medicine(all)

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