Transesophageal Echocardiography Improves Risk Assessment of Thrombolysis of Prosthetic Valve Thrombosis: Results of the International PRO-TEE Registry

Ann T. Tong, Raymond Roudaut, Mehmet Ozkan, Alex Sagie, Maie S A Shahid, Sergio C. Pontes, Francesc Carreras, Steven E. Girard, Samir Arnaout, Raymond F. Stainback, Ravi Thadhani, William A. Zoghbi

Research output: Contribution to journalArticlepeer-review

165 Scopus citations


OBJECTIVES: The goal of this study was to evaluate whether quantitation of thrombus burden with transesophageal echocardiography (TEE) can help risk-stratify patients undergoing thrombolysis of prosthetic valve thrombosis (PVT). BACKGROUND: Thrombolytic therapy of PVT has an unpredictable risk of embolization and complications. METHODS: An international registry of patients with suspected PVT undergoing two-dimensional/ Doppler and TEE before thrombolysis was established. All TEE studies were reviewed and quantitated by a single observer blinded to all data. RESULTS: From 1985 to 2001, 107 patients (71 females; age 24 to 86 years) from 14 centers (6 in the U.S.) were identified. The majority of cases involved the mitral valve (79 mitral, 13 aortic, and 15 tricuspid). Hemodynamic success rate was achieved in 85% and was similar across valves. Overall complications were observed in 17.8%, and death in 5.6%. Predictors of complications were: New York Heart Association (NYHA) functional class, presence of shock, sinus tachycardia, hypotension, previous history of stroke, thrombus extension beyond the valve ring, and thrombus area. Multivariate analysis demonstrated that two variables were independent predictors of complications: thrombus area by TEE (odds ratio [OR] 2.41 per 1 cm2 increment, 95% confidence interval [CI] 1.12 to 5.19) and prior history of stroke (OR 4.55, 95% CI 1.35 to 15.38). A thrombus area <0.8 cm2 identified patients at lower risk for complications from thrombolysis, irrespective of NYHA functional class. CONCLUSIONS: In PVT, the thrombus size imaged with TEE is a significant independent predictor of outcome. Transesophageal echocardiography can identify low-risk groups for thrombolysis irrespective of symptom severity and is therefore recommended in the management of prosthetic valve thrombosis.

Original languageEnglish (US)
Pages (from-to)77-84
Number of pages8
JournalJournal of the American College of Cardiology
Issue number1
StatePublished - Jan 7 2004

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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