Transdermal skin delivery: Predictions for humans from in vivo, ex vivo and animal models

Biana Godin, Elka Touitou

Research output: Contribution to journalReview articlepeer-review

436 Scopus citations

Abstract

The assessment of percutaneous permeation of molecules is one of the main steps in the initial design and later in the evaluation of dermal or transdermal drug delivery systems. The literature reports numerous ex vivo, in vitro and in vivo models used to determine drug skin permeation profiles and kinetic parameters, some studies focusing on the correlation of the data obtained using these models with the dermal/transdermal absorption in humans. This paper reviews work from in vitro permeation studies to clinical performance, presenting various experimental models used in dermal/transdermal research, including the use of excised human or animal skin, cultured skin equivalents and animals. Studies focusing on transdermal absorption of a series of drug molecules and various delivery systems as well as mathematical models for skin absorption are reviewed.

Original languageEnglish (US)
Pages (from-to)1152-1161
Number of pages10
JournalAdvanced Drug Delivery Reviews
Volume59
Issue number11
DOIs
StatePublished - Sep 30 2007

Keywords

  • Animal skin
  • In vitro-in vivo correlation
  • Percutaneous permeation
  • Skin equivalents
  • Studies in humans
  • Transdermal absorption

ASJC Scopus subject areas

  • Pharmaceutical Science

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