Transcriptome of rat subcortical white matter and spinal cord after spinal injury and cortical stimulation

Bethany R. Kondiles, Haichao Wei, Lesley S. Chaboub, Philip J. Horner, Jia Qian Wu, Steve I. Perlmutter

Research output: Contribution to journalArticlepeer-review

Abstract

Spinal cord injury disrupts ascending and descending neural signals causing sensory and motor dysfunction. Neuromodulation with electrical stimulation is used in both clinical and research settings to induce neural plasticity and improve functional recovery following spinal trauma. However, the mechanisms by which electrical stimulation affects recovery remain unclear. In this study we examined the effects of cortical electrical stimulation following injury on transcription at several levels of the central nervous system. We performed a unilateral, incomplete cervical spinal contusion injury in rats and delivered stimulation for one week to the contralesional motor cortex to activate the corticospinal tract and other pathways. RNA was purified from bilateral subcortical white matter and 3 levels of the spinal cord. Here we provide the complete data set in the hope that it will be useful for researchers studying electrical stimulation as a therapy to improve recovery from the deficits associated with spinal cord injury.

Original languageEnglish (US)
Article number175
JournalScientific Data
Volume8
Issue number1
DOIs
StatePublished - Dec 2021

ASJC Scopus subject areas

  • Statistics and Probability
  • Information Systems
  • Education
  • Computer Science Applications
  • Statistics, Probability and Uncertainty
  • Library and Information Sciences

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