Transcriptional signaling pathways inversely regulated in Alzheimer's disease and glioblastoma multiform

Timothy Liu, Ding Ren, Xiaoping Zhu, Zheng Yin, Guangxu Jin, Zhen Zhao, Daniel Robinson, Xuping Li, Kelvin Wong, Kemi Cui, Hong Zhao, Stephen T C Wong

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Convincing epidemiological data suggest an inverse association between cancer and neurodegeneration, including Alzheimer's disease (AD). Since both AD and cancer are characterized by abnormal, but opposing cellular behavior, i.e., increased cell death in AD while excessive cell growth occurs in cancer, this motivates us to initiate the study into unraveling the shared genes and cell signaling pathways linking AD and glioblastoma multiform (GBM). In this study, a comprehensive bioinformatics analysis on clinical microarray datasets of 1,091 GBM and 524 AD cohorts was performed. Significant genes and pathways were identified from the bioinformatics analyses - in particular ERK/MAPK signaling, up-regulated in GBM and Angiopoietin Signaling pathway, reciprocally up-regulated in AD - connecting GBM and AD (P < 0.001), were investigated in details for their roles in GBM growth in an AD environment. Our results showed that suppression of GBM growth in an AD background was mediated by the ERK-AKT-p21-cell cycle pathway and anti-angiogenesis pathway.

Original languageEnglish (US)
Article number3467
JournalScientific Reports
Volume3
DOIs
StatePublished - Dec 10 2013

ASJC Scopus subject areas

  • General

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