Transcriptional corepression by SHP: Molecular mechanisms and physiological consequences

Ann Båvner, Sabyasachi Sanyal, Jan Åke Gustafsson, Eckardt Treuter

Research output: Contribution to journalReview articlepeer-review

115 Scopus citations

Abstract

Small heterodimer partner (SHP; NR0B2), an exceptional member of the mammalian nuclear receptor family, directly modulates the activities of conventional nuclear receptors by acting as an inducible and tissue-specific corepressor. Recent progress in dissecting underlying molecular mechanisms, identifying target factors and target genes, and uncovering physiological functions points to the regulatory involvement of SHP in diverse metabolic and intracellular pathways that awaits future clarification. In this review, we carry out a comprehensive survey of all published data and discuss our current understanding of molecular mechanisms and physiological consequences governing SHP action.

Original languageEnglish (US)
Pages (from-to)478-488
Number of pages11
JournalTrends in Endocrinology and Metabolism
Volume16
Issue number10
DOIs
StatePublished - Dec 2005

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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