TY - JOUR
T1 - Transcriptional corepression by SHP
T2 - Molecular mechanisms and physiological consequences
AU - Båvner, Ann
AU - Sanyal, Sabyasachi
AU - Gustafsson, Jan Åke
AU - Treuter, Eckardt
N1 - Funding Information:
We apologize to all colleagues whose work could not be appropriately discussed and cited because of space limitations. We acknowledge the expert input of the anonymous referees. This work was supported by grants from the Swedish Research Council, the Swedish Cancer Society, the Swedish Society for Medical Research and the European Union Network of Excellence CASCADE.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2005/12
Y1 - 2005/12
N2 - Small heterodimer partner (SHP; NR0B2), an exceptional member of the mammalian nuclear receptor family, directly modulates the activities of conventional nuclear receptors by acting as an inducible and tissue-specific corepressor. Recent progress in dissecting underlying molecular mechanisms, identifying target factors and target genes, and uncovering physiological functions points to the regulatory involvement of SHP in diverse metabolic and intracellular pathways that awaits future clarification. In this review, we carry out a comprehensive survey of all published data and discuss our current understanding of molecular mechanisms and physiological consequences governing SHP action.
AB - Small heterodimer partner (SHP; NR0B2), an exceptional member of the mammalian nuclear receptor family, directly modulates the activities of conventional nuclear receptors by acting as an inducible and tissue-specific corepressor. Recent progress in dissecting underlying molecular mechanisms, identifying target factors and target genes, and uncovering physiological functions points to the regulatory involvement of SHP in diverse metabolic and intracellular pathways that awaits future clarification. In this review, we carry out a comprehensive survey of all published data and discuss our current understanding of molecular mechanisms and physiological consequences governing SHP action.
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U2 - 10.1016/j.tem.2005.10.005
DO - 10.1016/j.tem.2005.10.005
M3 - Review article
C2 - 16275121
AN - SCOPUS:27844509037
SN - 1043-2760
VL - 16
SP - 478
EP - 488
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 10
ER -