Transcriptional co-expression analysis of embryonic stem cells

Yu Sun; Ming Zhan

doi:10.2174/978160805025311201010109

Transcriptional co-expression analysis of embryonic stem cells

Yu Sun, Ming Zhan

Academic Institute

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The decision between differentiation and self-renewal of embryonic stem cells (ESCs) are controlled by a complex network formed by interacting genes or proteins. Identifying critical components of this regulatory network and exploring their behavior patterns is crucial towards understanding the underlying mechanisms controlling ESC differentiation and realizing their potentials in regenerative medicine. In this chapter, we describe the usage of co-expression analysis in identifying conserved and divergent genomic, transcriptomic, and network modules critical for the earliest stage of ESCs differentiation.

Original language	English (US)
Title of host publication	Computational Biology of Embryonic Stem Cells
Publisher	Bentham Science Publishers Ltd.
Pages	109-132
Number of pages	24
ISBN (Print)	9781608054343
DOIs	https://doi.org/10.2174/978160805025311201010109
State	Published - Dec 1 2012

Keywords

BMP
Cell cycle
Chromosomal domains
Co-expression
Comparative transcriptomics
Embryonic bodies
Embryonic stem cell
FGF
JAK/STAT
LIF
Nanog
Nodal
Oct4
Pluripotency
Sox2
TGF-β
Transcriptional module
Transcriptome mapping
Wnt

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.2174/978160805025311201010109

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Transcriptional co-expression analysis of embryonic stem cells

Abstract

Keywords

ASJC Scopus subject areas

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