Transcriptional co-expression analysis of embryonic stem cells

Yu Sun, Ming Zhan

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The decision between differentiation and self-renewal of embryonic stem cells (ESCs) are controlled by a complex network formed by interacting genes or proteins. Identifying critical components of this regulatory network and exploring their behavior patterns is crucial towards understanding the underlying mechanisms controlling ESC differentiation and realizing their potentials in regenerative medicine. In this chapter, we describe the usage of co-expression analysis in identifying conserved and divergent genomic, transcriptomic, and network modules critical for the earliest stage of ESCs differentiation.

Original languageEnglish (US)
Title of host publicationComputational Biology of Embryonic Stem Cells
PublisherBentham Science Publishers Ltd.
Pages109-132
Number of pages24
ISBN (Print)9781608054343
DOIs
StatePublished - Dec 1 2012

Keywords

  • BMP
  • Cell cycle
  • Chromosomal domains
  • Co-expression
  • Comparative transcriptomics
  • Embryonic bodies
  • Embryonic stem cell
  • FGF
  • JAK/STAT
  • LIF
  • Nanog
  • Nodal
  • Oct4
  • Pluripotency
  • Sox2
  • TGF-β
  • Transcriptional module
  • Transcriptome mapping
  • Wnt

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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