Abstract
The decision between differentiation and self-renewal of embryonic stem cells (ESCs) are controlled by a complex network formed by interacting genes or proteins. Identifying critical components of this regulatory network and exploring their behavior patterns is crucial towards understanding the underlying mechanisms controlling ESC differentiation and realizing their potentials in regenerative medicine. In this chapter, we describe the usage of co-expression analysis in identifying conserved and divergent genomic, transcriptomic, and network modules critical for the earliest stage of ESCs differentiation.
Original language | English (US) |
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Title of host publication | Computational Biology of Embryonic Stem Cells |
Publisher | Bentham Science Publishers Ltd. |
Pages | 109-132 |
Number of pages | 24 |
ISBN (Print) | 9781608054343 |
DOIs | |
State | Published - Dec 1 2012 |
Keywords
- BMP
- Cell cycle
- Chromosomal domains
- Co-expression
- Comparative transcriptomics
- Embryonic bodies
- Embryonic stem cell
- FGF
- JAK/STAT
- LIF
- Nanog
- Nodal
- Oct4
- Pluripotency
- Sox2
- TGF-β
- Transcriptional module
- Transcriptome mapping
- Wnt
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology