Transcriptional activity of HIV-1 and HHV-6 in retinal lesions from AIDS patients

H. B. Qavi, M. T. Green, G. K. SeGall, Dorothy E. Lewis, F. B. Hollinger

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

This study determined the frequency of multiple viral (HIV-1, HHV-6, and CMV) infections in 26 retinas from 16 AIDS patients. Of the 12 retinas of 26 that tested positive for HIV-1 DNA sequences, seven also were positive for HHV-6 DNA sequences. Four of these seven retinas were culture positive for HIV-1 and two of the four contained CMV DNA sequences and antigens. Using RNA probes, HIV-1 and HHV-6 transcriptional activity was demonstrated in two of the four HIV-1 culture positive retinas. These retinas also contained CMV DNA sequences and antigens. The results demonstrate that more than 35% of AIDS patients suffer from at least two simultaneous viral infections and 15% suffer from three viral infections. The presence of transcriptional activity of HIV-1 and HHV-6 suggests an active infection.

Original languageEnglish (US)
Pages (from-to)2759-2767
Number of pages9
JournalInvestigative Ophthalmology and Visual Science
Volume33
Issue number10
StatePublished - 1992

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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