Transcriptional activation of the HO-1 gene by lipopolysaccharide is mediated by 5′ distal enhancers: Role of reactive oxygen intermediates and AP-1

Medicine & Life Sciences

• Heme Oxygenase-1 98%
• Transcription Factor AP-1 93%
• Transcriptional Activation 76%
• Lipopolysaccharides 72%
• Oxygen 60%
• Genes 33%
• RAW 264.7 Cells 22%
• 5' Flanking Region 10%
• Transcription Initiation Site 9%
• Acetylcysteine 9%
• Dimethyl Sulfoxide 9%
• Electrophoretic Mobility Shift Assay 9%
• Heat-Shock Proteins 8%
• Northern Blotting 8%
• Signal Transduction 6%
• Transcription Factors 6%
• Antioxidants 6%
• Oxidative Stress 6%
• Macrophages 5%
• Gene Expression 5%
• Messenger RNA 4%

Chemistry

• Enhancer 100%
• Lipopolysaccharide 92%
• Heme 77%
• Dioxygen 40%
• N-Acetyl-L-Cysteine 12%
• Messenger RNA 11%
• Signal Transduction 9%
• Oxidative Stress 8%
• Dimethyl Sulfoxide 7%
• Antioxidant Agent 6%
• Protein 3%