Transcription factor PITX3 gene in Parkinson's disease

Weidong Le; Deanne Nguyen; Xiyao Wendy Lin; Pawan Rawal; Maosheng Huang; Yujian Ding; Wenjie Xie; Hao Deng; Joseph Jankovic

doi:10.1016/j.neurobiolaging.2009.03.015

Transcription factor PITX3 gene in Parkinson's disease

Weidong Le, Deanne Nguyen, Xiyao Wendy Lin, Pawan Rawal, Maosheng Huang, Yujian Ding, Wenjie Xie, Hao Deng, Joseph Jankovic

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

PITX3 is a transcription factor important for the differentiation and survival of midbrain dopaminergic neurons during the development. Recent reports suggest that single nucleotide polymorphisms (SNP) in the gene may be associated with Parkinson's disease (PD). To verify their findings and to determine the nature of the association in a subset of our PD patients we have analyzed two PITX3 SNPs (rs2281983 and rs4919621) in 265 PD patients and compared them with 210 age-matched healthy controls. Our data show that the substitutions of C/T in SNP1 and A/T in SNP2 are significantly higher in PD, and this finding is even more robust in young onset and familial PD as compared with age-matched healthy controls. Our findings indicate that PITX3 may play a role in the pathogenesis of PD.

Original language	English (US)
Pages (from-to)	750-753
Number of pages	4
Journal	Neurobiology of Aging
Volume	32
Issue number	4
DOIs	https://doi.org/10.1016/j.neurobiolaging.2009.03.015
State	Published - Apr 2011

Keywords

Dopaminergic neurons
Neurogenetics
Single nucleotide polymorphisms
Substantia nigra

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)
Aging
Developmental Biology
Geriatrics and Gerontology

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10.1016/j.neurobiolaging.2009.03.015

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title = "Transcription factor PITX3 gene in Parkinson's disease",

abstract = "PITX3 is a transcription factor important for the differentiation and survival of midbrain dopaminergic neurons during the development. Recent reports suggest that single nucleotide polymorphisms (SNP) in the gene may be associated with Parkinson's disease (PD). To verify their findings and to determine the nature of the association in a subset of our PD patients we have analyzed two PITX3 SNPs (rs2281983 and rs4919621) in 265 PD patients and compared them with 210 age-matched healthy controls. Our data show that the substitutions of C/T in SNP1 and A/T in SNP2 are significantly higher in PD, and this finding is even more robust in young onset and familial PD as compared with age-matched healthy controls. Our findings indicate that PITX3 may play a role in the pathogenesis of PD.",

keywords = "Dopaminergic neurons, Neurogenetics, Single nucleotide polymorphisms, Substantia nigra",

author = "Weidong Le and Deanne Nguyen and Lin, {Xiyao Wendy} and Pawan Rawal and Maosheng Huang and Yujian Ding and Wenjie Xie and Hao Deng and Joseph Jankovic",

note = "Funding Information: This study was supported by the Helis Foundation (W.L.) the National Parkinson Foundation to the Baylor College of Medicine Center of Excellence (J.J.) the National Natural Scientific Foundation of China (30871351, H.D.). The authors thank the participating patients for their cooperation, and thank Dr. William Ondo, and Anthony L. Davidson (Parkinson disease Center and Movement Disorder Clinic, Baylor College of Medicine, Houston, TX) for their efforts in collecting the genetic information and DNA specimens.",

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doi = "10.1016/j.neurobiolaging.2009.03.015",

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AU - Le, Weidong

AU - Nguyen, Deanne

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AU - Rawal, Pawan

AU - Huang, Maosheng

AU - Ding, Yujian

AU - Xie, Wenjie

AU - Deng, Hao

AU - Jankovic, Joseph

N1 - Funding Information: This study was supported by the Helis Foundation (W.L.) the National Parkinson Foundation to the Baylor College of Medicine Center of Excellence (J.J.) the National Natural Scientific Foundation of China (30871351, H.D.). The authors thank the participating patients for their cooperation, and thank Dr. William Ondo, and Anthony L. Davidson (Parkinson disease Center and Movement Disorder Clinic, Baylor College of Medicine, Houston, TX) for their efforts in collecting the genetic information and DNA specimens.

PY - 2011/4

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N2 - PITX3 is a transcription factor important for the differentiation and survival of midbrain dopaminergic neurons during the development. Recent reports suggest that single nucleotide polymorphisms (SNP) in the gene may be associated with Parkinson's disease (PD). To verify their findings and to determine the nature of the association in a subset of our PD patients we have analyzed two PITX3 SNPs (rs2281983 and rs4919621) in 265 PD patients and compared them with 210 age-matched healthy controls. Our data show that the substitutions of C/T in SNP1 and A/T in SNP2 are significantly higher in PD, and this finding is even more robust in young onset and familial PD as compared with age-matched healthy controls. Our findings indicate that PITX3 may play a role in the pathogenesis of PD.

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Transcription factor PITX3 gene in Parkinson's disease

Abstract

Keywords

ASJC Scopus subject areas

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