Purpose of reviewA significant number of patients with mitral valve disease are at high to prohibitive risk for surgical repair or replacement. Transcatheter mitral valve interventions have evolved over the last few years. We review the recent growing evidence on transcatheter mitral valve replacement (TMVR).Recent findingsTendyne is the first TMVR device commercially approved in Europe. All TMVR systems remain under investigation in the United States. Several early studies have reported the feasibility and safety outcomes for TMVR implanted via transapical or transseptal approach. TMVR using balloon expandable valve for degenerated bioprosthetic valves, surgical rings and mitral annular calcification appears feasible in selected patients.SummaryEarly experience with TMVR systems is promising. Larger ongoing studies will help understand longer term outcomes and offer insights into patient selection.

Original languageEnglish (US)
Pages (from-to)384-389
Number of pages6
JournalCurrent Opinion in Cardiology
Issue number4
StatePublished - Jul 1 2021


  • mitral annular calcification
  • mitral regurgitation
  • mitral valve-in-ring
  • mitral valve-in-valve
  • transcatheter mitral valve replacement

ASJC Scopus subject areas

  • Medicine(all)


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