TY - JOUR
T1 - Tracking methicillin-resistant Staphylococcus aureus clones in Colombian hospitals over 7 years (1996-2003)
T2 - Emergence of a new dominant clone
AU - Cruz, César
AU - Moreno, Jaime
AU - Renzoni, Adriana
AU - Hidalgo, Marilyn
AU - Reyes, Jinnethe
AU - Schrenzel, Jacques
AU - Lew, Daniel
AU - Castañeda, Elizabeth
AU - Arias, César A.
N1 - Funding Information:
Partial support for this study was provided by the Fond de Péréquation (Hôpital Cantonal de Genève) grants from Suisse National Research Foundation (No. 3200BBO-108401 and No. PP00B—103002/1) and the Instituto Colombiano para el Desarrollo de la Ciencia y Tecnologia, ‘Francisco Jose de Caldas’, Code: 2104-04-12685. We thank H. de Lencastre, Instituto de Tecnologia Quimica e Biologica, Oeiras, Portugal and Rockefeller University, New York, USA, for the gift of PFGE control strains and gel photograph comparisons. We are grateful to Sasi Darhman from Geneva University Hospital and to Carlos Chiriboga from the Molecular Biology Laboratory, Universidad El Bosque, Bogotá, for technical assistance.
PY - 2005/12
Y1 - 2005/12
N2 - Worldwide dissemination of methicillin-resistant Staphylococcus aureus (MRSA) clones is a well-characterised phenomenon. Two hundred isolates of MRSA recovered from 17 Colombian hospitals collected between 2001 and 2003 were characterised by pulsed-field gel electrophoresis (PFGE). A new dominant electrophoretic pattern unrelated to previously characterised clones in Colombia was detected in 137 (68.5%) of these isolates. Only 40 (20%) isolates still showed a pattern closely related to a previously described dominant clone. The new electrophoretic pattern was indistinguishable from a cluster of isolates recovered in Chile between 1996 and 1998. Isolates from this clonal cluster exhibited multidrug resistance but were susceptible to linezolid and glycopeptides. The results indicate a shift in the population genetics of Colombian MRSA and confirm dissemination of the Chilean clone for the first time.
AB - Worldwide dissemination of methicillin-resistant Staphylococcus aureus (MRSA) clones is a well-characterised phenomenon. Two hundred isolates of MRSA recovered from 17 Colombian hospitals collected between 2001 and 2003 were characterised by pulsed-field gel electrophoresis (PFGE). A new dominant electrophoretic pattern unrelated to previously characterised clones in Colombia was detected in 137 (68.5%) of these isolates. Only 40 (20%) isolates still showed a pattern closely related to a previously described dominant clone. The new electrophoretic pattern was indistinguishable from a cluster of isolates recovered in Chile between 1996 and 1998. Isolates from this clonal cluster exhibited multidrug resistance but were susceptible to linezolid and glycopeptides. The results indicate a shift in the population genetics of Colombian MRSA and confirm dissemination of the Chilean clone for the first time.
KW - Antibiotic resistance
KW - Methicillin-resistant Staphylococcus aureus
KW - Molecular epidemiology
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U2 - 10.1016/j.ijantimicag.2005.08.013
DO - 10.1016/j.ijantimicag.2005.08.013
M3 - Article
C2 - 16278073
AN - SCOPUS:27744594661
SN - 0924-8579
VL - 26
SP - 457
EP - 462
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
IS - 6
ER -