@inbook{e72f2274226548cd9f8dcd18dccccdcf,
title = "Tracking Metabolic Rewiring of Cancer Metabolism in Humans Using Isotope-Resolved NMR",
abstract = "Altered metabolism is considered one of the hallmarks of cancer. The findings that malignant brain tumors and brain metastases utilize acetate as an alternative nutrient are relatively recent and offer new avenues for investigation of altered metabolism in human cancers. Here, we describe comprehensively the details of the 13C NMR-based isotopomer methodology to measure in vivo acetate utilization in brain tumor patients, including the contribution from acetate metabolism of peripheral tissues. Methods described in this chapter can be readily extended to other cancer types.",
keywords = "Acetyl-CoA, C NMR, Citric acid cycle, C–C spin–spin coupling, Isotopomer, Pyruvate recycling, [1,2-C]acetate",
author = "Kumar Pichumani",
note = "Funding Information: This work was supported by Donna and Kenneth Peak, The Kenneth R. Peak Foundation, The Kenneth R. Peak Brain and Pituitary Tumor Treatment Center at Houston Methodist Hospital, The Houston Methodist Foundation, The Taub Foundation, The Pauline Sterne Wolff Foundation, The Veralan Foundation, The Mar-ilee A. and Gary M. Schwarz Foundation, The John S. Dunn Foundation and The McKone Family Foundation. We are grateful to the many patients and their families who have participated in our studies, and who are dedicated to join us in our fight against brain cancer. Funding Information: This work was supported by Donna and Kenneth Peak, The Kenneth R. Peak Foundation, The Kenneth R. Peak Brain and Pituitary Tumor Treatment Center at Houston Methodist Hospital, The Houston Methodist Foundation, The Taub Foundation, The Pauline Sterne Wolff Foundation, The Veralan Foundation, The Marilee A. and Gary M. Schwarz Foundation, The John S. Dunn Foundation and The McKone Family Foundation. We are grateful to the many patients and their families who have participated in our studies, and who are dedicated to join us in our fight against brain cancer. Publisher Copyright: {\textcopyright} Springer Science+Business Media, LLC, part of Springer Nature 2019. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",
year = "2019",
doi = "10.1007/978-1-4939-9690-2_10",
language = "English (US)",
series = "Methods in Molecular Biology",
publisher = "Humana Press",
pages = "169--186",
booktitle = "Methods in Molecular Biology",
}