TY - JOUR
T1 - Tracking differential activation of primary and supplementary motor cortex across timing tasks
T2 - An fNIRS validation study
AU - Rahimpour, Ali
AU - Pollonini, Luca
AU - Comstock, Daniel
AU - Balasubramaniam, Ramesh
AU - Bortfeld, Heather
N1 - Funding Information:
The work was partially supported by NIDCDR01 DC010075 to HB, and by NSFBCS 1460633, NSF DGE 1633722 to RB.
Funding Information:
The work was partially supported by NIDCD R01 DC010075 to HB, and by NSF BCS 1460633 , NSF DGE 1633722 to RB.
Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/7/15
Y1 - 2020/7/15
N2 - Functional near-infrared spectroscopy (fNIRS) provides an alternative to functional magnetic resonance imaging (fMRI) for assessing changes in cortical hemodynamics. To establish the utility of fNIRS for measuring differential recruitment of the motor network during the production of timing-based actions, we measured cortical hemodynamic responses in 10 healthy adults while they performed two versions of a finger-tapping task. The task, used in an earlier fMRI study (Jantzen et al., 2004), was designed to track the neural basis of different timing behaviors. Participants paced their tapping to a metronomic tone, then continued tapping at the established pace without the tone. Initial tapping was either synchronous or syncopated relative to the tone. This produced a 2 × 2 design: synchronous or syncopated tapping and pacing the tapping with or continuing without a tone. Accuracy of the timing of tapping was tracked while cortical hemodynamics were monitored using fNIRS. Hemodynamic responses were computed by canonical statistical analysis across trials in each of the four conditions. Task-induced brain activation resulted in significant increases in oxygenated hemoglobin concentration (oxy-Hb) in a broad region in and around the motor cortex. Overall, syncopated tapping was harder behaviorally and produced more cortical activation than synchronous tapping. Thus, we observed significant changes in oxy-Hb in direct relation to the complexity of the task.
AB - Functional near-infrared spectroscopy (fNIRS) provides an alternative to functional magnetic resonance imaging (fMRI) for assessing changes in cortical hemodynamics. To establish the utility of fNIRS for measuring differential recruitment of the motor network during the production of timing-based actions, we measured cortical hemodynamic responses in 10 healthy adults while they performed two versions of a finger-tapping task. The task, used in an earlier fMRI study (Jantzen et al., 2004), was designed to track the neural basis of different timing behaviors. Participants paced their tapping to a metronomic tone, then continued tapping at the established pace without the tone. Initial tapping was either synchronous or syncopated relative to the tone. This produced a 2 × 2 design: synchronous or syncopated tapping and pacing the tapping with or continuing without a tone. Accuracy of the timing of tapping was tracked while cortical hemodynamics were monitored using fNIRS. Hemodynamic responses were computed by canonical statistical analysis across trials in each of the four conditions. Task-induced brain activation resulted in significant increases in oxygenated hemoglobin concentration (oxy-Hb) in a broad region in and around the motor cortex. Overall, syncopated tapping was harder behaviorally and produced more cortical activation than synchronous tapping. Thus, we observed significant changes in oxy-Hb in direct relation to the complexity of the task.
KW - AR-IRLS
KW - Canonical statistical analysis
KW - Continuation paradigm
KW - Finger tapping task
KW - HRF
KW - Simple motor timing task
KW - Temporal motor task
KW - fNIRS
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U2 - 10.1016/j.jneumeth.2020.108790
DO - 10.1016/j.jneumeth.2020.108790
M3 - Article
C2 - 32442439
AN - SCOPUS:85085639863
VL - 341
JO - Journal of Neuroscience Methods
JF - Journal of Neuroscience Methods
SN - 0165-0270
M1 - 108790
ER -