Tracking changes over time in retinal nerve fiber layer and ganglion cell-inner plexiform layer thickness in multiple sclerosis

DIvya Narayanan, Han Cheng, Karlie N. Bonem, Roberto Saenz, Rosa A. Tang, Laura J. Frishman

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

Background: Neurodegeneration plays an important role in permanent disability in multiple sclerosis (MS). Objective: The objective of this paper is to determine whether progressive neurodegeneration occurs in MS eyes without clinically evident inflammation. Methods: Retinal nerve fiver layer thickness (RNFLT) and ganglion cell-inner plexiform layer thickness (GCIPT) were measured using Cirrus optical coherence tomography (OCT) in 133 relapsing-remitting MS (RRMS) patients (149 nonoptic neuritis (ON), 97 ON eyes, last ON ?6 months). Ninety-three patients were scanned at two visits. Percentages of abnormal GCIPT vs RNFLT (<5% of machine norms) in cross-sectional data were compared. Relations between RNFLT/ GCIPT and MS duration (cross-sectional) and follow-up time (longitudinal) were assessed. Results: GCIPT was abnormal in more eyes than RNFLT (27% vs 16% p = 0.004 in non-ON, 82% vs 72% p = 0.007 in ON). RNFLT and GCIPT decreased with MS duration by ?0.49 ?m/yr (p = 0.0001) and ?0.36 (p = 0.005) for non-ON; ?0.52 (p = 0.003) and ?0.41 (p = 0.007) for ON. RNFLT and GCIPT decreased with follow-up time by ?1.49 ?m/yr (p < 0.0001) and ?0.53 (p = 0.004) for non-ON, ?1.27 (p = 0.002) and ?0.49 (p = 0.04) for ON. Conclusions: In RRMS eyes without clinically evident inflammation, progressive loss of RNFLT and GCIPT occurred, supporting the need for neuroprotection in addition to suppression of autoimmune responses and inflammation.

Original languageEnglish (US)
Pages (from-to)1331-1341
Number of pages11
JournalMultiple Sclerosis
Volume20
Issue number10
DOIs
StatePublished - Sep 2014

Keywords

  • Ganglion cell inner plexiform layer
  • Multiple sclerosis
  • Neurodegeneration
  • Optic neuritis
  • Optical coherence tomography
  • Retinal nerve fiber layer

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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