Tracheal and bronchial cartilaginous rings: Warfarin sodium-induced calcification

Rogelio M. Moncada; Luz A. Venta; Enrique R. Venta; Jawed Fareed; Jeanine M. Walenga; Harry L. Messmore

doi:10.1148/radiology.184.2.1620843

Tracheal and bronchial cartilaginous rings: Warfarin sodium-induced calcification

Rogelio M. Moncada, Luz A. Venta, Enrique R. Venta, Jawed Fareed, Jeanine M. Walenga, Harry L. Messmore

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Progressive calcification of the cartilaginous rings (CCR) of the trachea and bronchi has been observed in patients undergoing prolonged prophylactic anticoagulant therapy with warfarin sodium. The purpose of this study was to validate the relationship of warfarin sodium and CCR, as well as to present the appearance and sex and age distribution of the normal degenerative CCR seen in the elderly. Chest radiographs were scrutinized for evidence of CCR in 92 patients who underwent warfarin sodium therapy and in 105 patients used as a control group. CCR was classified as not present (scored as 0), subtle (scored as 1), and extensive (scored as 2). In the warfarin sodium study group, 47% of patients (43 of 92) exhibited level 1 or level 2 CCR. This proportion was 19% (20 of 105) in the control group. The difference was statistically significant (P < .001). A significant positive correlation (P < .001) was also present between the duration of warfarin sodium therapy and increased levels of CCR.

Original language	English (US)
Pages (from-to)	437-439
Number of pages	3
Journal	Radiology
Volume	184
Issue number	2
DOIs	https://doi.org/10.1148/radiology.184.2.1620843
State	Published - Jan 1 1992

Keywords

Anticoagulants
Bronchi, abnormalities, 671.659, 671.81
Mitral valve, prostheses, 534.4614
Trachea, abnormalities, 671.659, 671.81

ASJC Scopus subject areas

Radiological and Ultrasound Technology

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10.1148/radiology.184.2.1620843

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title = "Tracheal and bronchial cartilaginous rings: Warfarin sodium-induced calcification",

abstract = "Progressive calcification of the cartilaginous rings (CCR) of the trachea and bronchi has been observed in patients undergoing prolonged prophylactic anticoagulant therapy with warfarin sodium. The purpose of this study was to validate the relationship of warfarin sodium and CCR, as well as to present the appearance and sex and age distribution of the normal degenerative CCR seen in the elderly. Chest radiographs were scrutinized for evidence of CCR in 92 patients who underwent warfarin sodium therapy and in 105 patients used as a control group. CCR was classified as not present (scored as 0), subtle (scored as 1), and extensive (scored as 2). In the warfarin sodium study group, 47% of patients (43 of 92) exhibited level 1 or level 2 CCR. This proportion was 19% (20 of 105) in the control group. The difference was statistically significant (P < .001). A significant positive correlation (P < .001) was also present between the duration of warfarin sodium therapy and increased levels of CCR.",

keywords = "Anticoagulants, Bronchi, abnormalities, 671.659, 671.81, Mitral valve, prostheses, 534.4614, Trachea, abnormalities, 671.659, 671.81",

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T2 - Warfarin sodium-induced calcification

AU - Moncada, Rogelio M.

AU - Venta, Luz A.

AU - Venta, Enrique R.

AU - Fareed, Jawed

AU - Walenga, Jeanine M.

AU - Messmore, Harry L.

PY - 1992/1/1

Y1 - 1992/1/1

N2 - Progressive calcification of the cartilaginous rings (CCR) of the trachea and bronchi has been observed in patients undergoing prolonged prophylactic anticoagulant therapy with warfarin sodium. The purpose of this study was to validate the relationship of warfarin sodium and CCR, as well as to present the appearance and sex and age distribution of the normal degenerative CCR seen in the elderly. Chest radiographs were scrutinized for evidence of CCR in 92 patients who underwent warfarin sodium therapy and in 105 patients used as a control group. CCR was classified as not present (scored as 0), subtle (scored as 1), and extensive (scored as 2). In the warfarin sodium study group, 47% of patients (43 of 92) exhibited level 1 or level 2 CCR. This proportion was 19% (20 of 105) in the control group. The difference was statistically significant (P < .001). A significant positive correlation (P < .001) was also present between the duration of warfarin sodium therapy and increased levels of CCR.

AB - Progressive calcification of the cartilaginous rings (CCR) of the trachea and bronchi has been observed in patients undergoing prolonged prophylactic anticoagulant therapy with warfarin sodium. The purpose of this study was to validate the relationship of warfarin sodium and CCR, as well as to present the appearance and sex and age distribution of the normal degenerative CCR seen in the elderly. Chest radiographs were scrutinized for evidence of CCR in 92 patients who underwent warfarin sodium therapy and in 105 patients used as a control group. CCR was classified as not present (scored as 0), subtle (scored as 1), and extensive (scored as 2). In the warfarin sodium study group, 47% of patients (43 of 92) exhibited level 1 or level 2 CCR. This proportion was 19% (20 of 105) in the control group. The difference was statistically significant (P < .001). A significant positive correlation (P < .001) was also present between the duration of warfarin sodium therapy and increased levels of CCR.

KW - Anticoagulants

KW - Bronchi, abnormalities, 671.659, 671.81

KW - Mitral valve, prostheses, 534.4614

KW - Trachea, abnormalities, 671.659, 671.81

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Tracheal and bronchial cartilaginous rings: Warfarin sodium-induced calcification

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Keywords

ASJC Scopus subject areas

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