Trace metal disturbance in mice brain after intranasal exposure of nano- and submicron-sized Fe2O3 particles

Bing Wang, Yun Wang, Weiyue Feng, Motao Zhu, Meng Wang, Hong Ouyang, Huajian Wang, Ming Li, Yuliang Zhao, Zhifang Chai

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Trace metals in the brain play an important role in the function of central nervous system (CNS). The objective of this work is to investigate the effects of intranasal exposure of nano- and submicron-sized Fe2O3 particles on the homeostasis of trace metals in the brain. After a single intranasal instillation of nano- and submicron-sized Fe2O3 particles, the con-tents of Fe, Cu and Zn in the sub-brain regions were determined in the time course from 4 h till to the 30 day post-exposure. Our results indicated that the imbalance of trace metals in the sub-brain regions of mice was induced by the two sizes of Fe2O3 particles. The more significant accumulation of Fe in the brain was found in the nano-Fe 2O3 treated mice than in the submicron-Fe 2O3 treated ones: meanwhile, similar alterations of Zn contents in the brain were observed as well. A strong positive correlation between Fe and Zn levels in the olfactory bulb of nano-Fe2O 3 instilled mice and in the hippocampus and cerebral cortex of submicron-Fe2O3 instilled mice were found. This is the first trial to investigate the disturbance of trace metals in the brain after exposure to Fe2O3 nanoparticles. These results state that much attention should be paid to the potential impact of inhaled Fe 2O3 nanoparticles on the CNS.

Original languageEnglish (US)
Pages (from-to)927-942
Number of pages16
JournalChemia Analityczna
Volume53
Issue number6
StatePublished - Dec 1 2008

Keywords

  • FeO nanoparticles
  • ICP-MS
  • NAA
  • Trace metals in mice brain: Cu, Zn

ASJC Scopus subject areas

  • Analytical Chemistry

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