TPGS-stabilized NaYbF4: ER Upconversion nanoparticles for dual-modal fluorescent/CT imaging and anticancer drug delivery to overcome multi-drug resistance

Gan Tian, Xiaopeng Zheng, Xiao Zhang, Wenyan Yin, Jie Yu, Dongliang Wang, Zhiping Zhang, Xiangliang Yang, Zhanjun Gu, Yuliang Zhao

Research output: Contribution to journalArticlepeer-review

145 Scopus citations

Abstract

Multi-drug resistance (MDR) is a major cause of failure in cancer chemotherapy. Tocopheryl polyethylene glycol 1000 succinate (TPGS) has been extensively investigated for overcoming MDR in cancer therapy because of its ability to inhibit P-glycoprotein (P-gp). In this work, TPGS was for the first time used as a new surface modifier to functionalize NaYbF4:Er upconversion nanoparticles (UNCPs) and endowed the as-prepared products (TPGS-UCNPs) with excellent water-solubility, P-gp inhibition capability and imaging-guided drug delivery property. After the chemotherapeutic drug (doxorubicin, DOX) loading, the as-formed composites (TPGS-UCNPs-DOX) exhibited potent killing ability for DOX-resistant MCF-7 cells. Flow-cytometric assessment and Western blot assay showed that the TPGS-UCNPs could potently decrease the P-gp expression and facilitate the intracellular drug accumulation, thus achieving MDR reversal. Moreover, considering that UCNPs process efficient upconversion emission and Yb element contained in UCNPs has strong X-ray attenuation ability, the as-obtained composite could also serve as a dual-modal probe for upconversion luminescence (UCL) imaging and X-ray computed tomography (CT) imaging, making them promising for imaging-guided cancer therapy.

Original languageEnglish (US)
Pages (from-to)107-116
Number of pages10
JournalBiomaterials
Volume40
DOIs
StatePublished - Feb 1 2015

Keywords

  • Multi-drug resistance
  • P-gp inhibition
  • TPGS
  • Theranostics
  • Upconversion nanoparticles

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Ceramics and Composites
  • Biomaterials
  • Mechanics of Materials

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