TY - JOUR
T1 - Towards an implantable biochip for glucose and lactate monitoring using microdisc electrode arrays (MDEAs)
AU - Abdur Rahman, Abdur Rub
AU - Justin, Gusphyl
AU - Guiseppi-Elie, Anthony
N1 - Funding Information:
Acknowledgements This work was supported by the US Department of Defense (DoDPRMRP) grant PR023081/DAMD17-03-1-0172 and by the Consortium of the Clemson University Center for Bioelectronics, Biosensors and Biochips. The authors acknowledge work to order contributions of Peter Hansen at Telesensors.
PY - 2009
Y1 - 2009
N2 - A complete electrochemical cell-on-a-chip that uses the MicroDisc Electrode Array (MDEA) working electrode (WE) design was evaluated for eventual intramuscular implantation for the continuous amperometric monitoring of glucose and lactate in an animal trauma model. The microfabricated ECC MDEA5037 comprises two discrete electrochemical cells-on-a-chip (ECCs), each with a reference, counter, and MDEA working electrode. Each MDEA comprises 37 microdiscs (diameter = 50 μm) arranged in a Hexagonal Closed Packed (HCP) arrangement with a center to center distance (d) of 100 μm. Cyclic Voltammetry (CV) and Electrical Impendence Spectroscopy (EIS) reveals that this device scales in its interfacial properties with a corresponding MDEA 050 device that comprises 5,184 microdiscs. Parallel development of miniaturized mixed-signal integrated electronics for wireless reprogramming, data acquisition and communication addresses the key issues involved in developing measurement electronics, AD/DA processing, power management and telemetry for implantable amperometric biosensors. A generalized electronics platform based on the Texas Instruments TI NC01101 chip has been developed that may be readily applied to many types of biotransducers with minor modifications.
AB - A complete electrochemical cell-on-a-chip that uses the MicroDisc Electrode Array (MDEA) working electrode (WE) design was evaluated for eventual intramuscular implantation for the continuous amperometric monitoring of glucose and lactate in an animal trauma model. The microfabricated ECC MDEA5037 comprises two discrete electrochemical cells-on-a-chip (ECCs), each with a reference, counter, and MDEA working electrode. Each MDEA comprises 37 microdiscs (diameter = 50 μm) arranged in a Hexagonal Closed Packed (HCP) arrangement with a center to center distance (d) of 100 μm. Cyclic Voltammetry (CV) and Electrical Impendence Spectroscopy (EIS) reveals that this device scales in its interfacial properties with a corresponding MDEA 050 device that comprises 5,184 microdiscs. Parallel development of miniaturized mixed-signal integrated electronics for wireless reprogramming, data acquisition and communication addresses the key issues involved in developing measurement electronics, AD/DA processing, power management and telemetry for implantable amperometric biosensors. A generalized electronics platform based on the Texas Instruments TI NC01101 chip has been developed that may be readily applied to many types of biotransducers with minor modifications.
KW - Biotransducers
KW - Implantable biosensors
KW - Integrated biochips
KW - Microarrays
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U2 - 10.1007/s10544-008-9211-6
DO - 10.1007/s10544-008-9211-6
M3 - Article
C2 - 18677565
AN - SCOPUS:59949095989
SN - 1387-2176
VL - 11
SP - 75
EP - 85
JO - Biomedical Microdevices
JF - Biomedical Microdevices
IS - 1
ER -