Toward better drug repositioning: Prioritizing and integrating existing methods into efficient pipelines

Guangxu Jin, Stephen T.C. Wong

Research output: Contribution to journalReview article

200 Scopus citations

Abstract

Recycling old drugs, rescuing shelved drugs and extending patents' lives make drug repositioning an attractive form of drug discovery. Drug repositioning accounts for approximately 30% of the newly US Food and Drug Administration (FDA)-approved drugs and vaccines in recent years. The prevalence of drug-repositioning studies has resulted in a variety of innovative computational methods for the identification of new opportunities for the use of old drugs. Questions often arise from customizing or optimizing these methods into efficient drug-repositioning pipelines for alternative applications. It requires a comprehensive understanding of the available methods gained by evaluating both biological and pharmaceutical knowledge and the elucidated mechanism-of-action of drugs. Here, we provide guidance for prioritizing and integrating drug-repositioning methods for specific drug-repositioning pipelines.

Original languageEnglish (US)
Pages (from-to)637-644
Number of pages8
JournalDrug Discovery Today
Volume19
Issue number5
DOIs
StatePublished - May 2014

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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