Toward better drug repositioning: Prioritizing and integrating existing methods into efficient pipelines

Guangxu Jin, Stephen T.C. Wong

Research output: Contribution to journalReview articlepeer-review

237 Scopus citations

Abstract

Recycling old drugs, rescuing shelved drugs and extending patents' lives make drug repositioning an attractive form of drug discovery. Drug repositioning accounts for approximately 30% of the newly US Food and Drug Administration (FDA)-approved drugs and vaccines in recent years. The prevalence of drug-repositioning studies has resulted in a variety of innovative computational methods for the identification of new opportunities for the use of old drugs. Questions often arise from customizing or optimizing these methods into efficient drug-repositioning pipelines for alternative applications. It requires a comprehensive understanding of the available methods gained by evaluating both biological and pharmaceutical knowledge and the elucidated mechanism-of-action of drugs. Here, we provide guidance for prioritizing and integrating drug-repositioning methods for specific drug-repositioning pipelines.

Original languageEnglish (US)
Pages (from-to)637-644
Number of pages8
JournalDrug Discovery Today
Volume19
Issue number5
DOIs
StatePublished - May 2014

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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