Toward a genome-scale understanding of group A Streptococcus pathogenesis

Morag R. Graham, Laura M. Smoot, Ben Fang Lei, James M. Musser

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Recent significant contributions have been made to the understanding of Group A Streptococcus (GAS) pathogenesis. New regulatory pathways have been discovered, insight into the molecular basis of epidemics of serotype M1 disease has been obtained, the crystal structures of four toxins have been reported and a genome sequence of one GAS strain has been determined. Genome-scale approaches to the study of GAS pathogenesis are now rapidly emerging and will advance our fundamental understanding of the molecular basis of host-pathogen interactions.

Original languageEnglish (US)
Pages (from-to)65-70
Number of pages6
JournalCurrent Opinion in Microbiology
Issue number1
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases


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