Total knee arthroplasty in a patient with nail-patella syndrome (NPS)

Maile E. Curbo, Kwan J. Park, Landon D. Brown, Stephen J. Incavo

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Nail-patella syndrome (NPS) or hereditary onycho-osteodyaplasia is a rare genetic condition involving a mutation in the LMX1B gene affecting nails, elbows, knees, and pelvis. Due to the regulatory functions of the gene in many developmental processes through the body, patients with NPS experience wide-ranging musculoskeletal problems including patellar instability, fingernail anomalies, iliac exostoses/horns, and elbow abnormalities. The patellar changes often involve aplasia, hypoplasia, and chronic dislocation. Due to these musculoskeletal involvement, arthritis of joints can occur in patients with NPS causing severe pain and disability. This is a case report of a patient with NPS who underwent a total knee arthroplasty for symptomatic knee arthritis.

Original languageEnglish (US)
Pages (from-to)273-278
Number of pages6
Issue number1
StatePublished - Jan 2019


  • Arthritis
  • Nail-patella syndrome
  • Onychoosteodysplasia
  • Patellar instability
  • Total knee arthroplasty

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine


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