TY - JOUR
T1 - Total Aqueous Synthesis of Au@Cu2−xS Core–Shell Nanoparticles for In Vitro and In Vivo SERS/PA Imaging-Guided Photothermal Cancer Therapy
AU - Lv, Qian
AU - Min, Huan
AU - Duan, Dong Ban
AU - Fang, Wei
AU - Pan, Gui Ming
AU - Shen, Ai Guo
AU - Wang, Qu Quan
AU - Nie, Guangjun
AU - Hu, Ji Ming
PY - 2019/1/24
Y1 - 2019/1/24
N2 - Both accurate tumor navigation and nanostructures with high photothermal (PT) conversion efficiency are important but remain challenging to achieve in current biomedical applications. This study reports an anion exchange-based facile and green approach for synthesizing Au@Cu2−xS core–shell nanoparticles (NPs) in an aqueous system. In addition to the PT effect of the suggested NPs, the surface-enhanced Raman scattering (SERS) is also significantly improved due to the tailored localized surface plasmon resonance coupling between the Au metal core and the Cu2−xS semiconductor shell. Using an epitaxial strategy, Au@Cu2O NPs are first obtained by the in situ reduction of cupric hydroxide on a cresyl violet acetate-coated Au core; then, Au@Cu2−xS NPs are obtained via anion exchange between the S2− and Cu2O shell. Both the Cu/S atomic ratio and the Cu2−xS shell thickness can be adjusted conveniently. Hence, the ideal integration of the plasmonic Au core and Cu2−xS shell into a single unit is conducive not only to highly efficient PT conversion but also to the construction of a SERS-based navigator. This new type of SERS-guided NP, with enhanced photoacoustic signals, is an important candidate for both accurate tumor navigation and nondestructive PT treatment guided in vivo by two modes of optical imaging.
AB - Both accurate tumor navigation and nanostructures with high photothermal (PT) conversion efficiency are important but remain challenging to achieve in current biomedical applications. This study reports an anion exchange-based facile and green approach for synthesizing Au@Cu2−xS core–shell nanoparticles (NPs) in an aqueous system. In addition to the PT effect of the suggested NPs, the surface-enhanced Raman scattering (SERS) is also significantly improved due to the tailored localized surface plasmon resonance coupling between the Au metal core and the Cu2−xS semiconductor shell. Using an epitaxial strategy, Au@Cu2O NPs are first obtained by the in situ reduction of cupric hydroxide on a cresyl violet acetate-coated Au core; then, Au@Cu2−xS NPs are obtained via anion exchange between the S2− and Cu2O shell. Both the Cu/S atomic ratio and the Cu2−xS shell thickness can be adjusted conveniently. Hence, the ideal integration of the plasmonic Au core and Cu2−xS shell into a single unit is conducive not only to highly efficient PT conversion but also to the construction of a SERS-based navigator. This new type of SERS-guided NP, with enhanced photoacoustic signals, is an important candidate for both accurate tumor navigation and nondestructive PT treatment guided in vivo by two modes of optical imaging.
KW - Au@CuS core–shell nanoparticles (NPs)
KW - navigation treatment
KW - photothermal therapy (PTT)
KW - plasmonic enhancement
KW - surface-enhanced Raman scattering (SERS)
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U2 - 10.1002/adhm.201801257
DO - 10.1002/adhm.201801257
M3 - Article
C2 - 30548216
AN - SCOPUS:85058013508
VL - 8
JO - Advanced Healthcare Materials
JF - Advanced Healthcare Materials
SN - 2192-2640
IS - 2
M1 - 1801257
ER -