TY - JOUR
T1 - Toscana meningoencephalitis
T2 - A comparison to other viral central nervous system infections
AU - Jaijakul, Siraya
AU - Arias, Cesar A.
AU - Hossain, Monir
AU - Arduino, Roberto C.
AU - Wootton, Susan H.
AU - Hasbun, Rodrigo
N1 - Funding Information:
The study was funded by National Center for Research Resources ( NIH-1 K23 RR018929-01A2 ) (PI. Hasbun), Tulane-LSU General Clinical Research Center RR05096 , National Institutes of Health Clinical and Translational Award UL1 RR024148 , and the Grant A Starr Foundation (PI Wootton).
PY - 2012/11
Y1 - 2012/11
N2 - Background: Toscana virus (TOSV) is an emerging pathogen causing central nervous system (CNS) infection in Mediterranean countries, mostly during summer season. Objectives: To compare the clinical and laboratory characteristics of Toscana CNS infections to the most common viral pathogens seen in the United States. Study design: We performed a case series of patients with 41 TOSV infection and compared the clinical characteristics, laboratory findings, imaging results and clinical outcomes to the most commonly recognized viral causes of meningoencephalitis in the US [enterovirus (n=60), herpes simplex virus (n=48), and West Nile virus (n=30)] from our multi-center study of patients with aseptic meningoencephalitis syndromes in the Greater Houston area. Results: TOSV infection occurs in different age groups compared to enterovirus, HSV, and WNV. All infections most frequently occur during summer-fall except HSV which distributes throughout the year. All patients with TOSV had history of travel to endemic areas. There are differences in clinical presentation and CSF findings comparing TOSV and enterovirus, HSV, and WNV infection. There are no significant differences in outcomes of each infection except WNV meningoencephalitis which had a poorer outcome compared to TOSV infection. Conclusions: TOSV is an emerging pathogen that should be considered in the differential diagnosis of patients with CNS infections and a recent travel history to endemic areas.
AB - Background: Toscana virus (TOSV) is an emerging pathogen causing central nervous system (CNS) infection in Mediterranean countries, mostly during summer season. Objectives: To compare the clinical and laboratory characteristics of Toscana CNS infections to the most common viral pathogens seen in the United States. Study design: We performed a case series of patients with 41 TOSV infection and compared the clinical characteristics, laboratory findings, imaging results and clinical outcomes to the most commonly recognized viral causes of meningoencephalitis in the US [enterovirus (n=60), herpes simplex virus (n=48), and West Nile virus (n=30)] from our multi-center study of patients with aseptic meningoencephalitis syndromes in the Greater Houston area. Results: TOSV infection occurs in different age groups compared to enterovirus, HSV, and WNV. All infections most frequently occur during summer-fall except HSV which distributes throughout the year. All patients with TOSV had history of travel to endemic areas. There are differences in clinical presentation and CSF findings comparing TOSV and enterovirus, HSV, and WNV infection. There are no significant differences in outcomes of each infection except WNV meningoencephalitis which had a poorer outcome compared to TOSV infection. Conclusions: TOSV is an emerging pathogen that should be considered in the differential diagnosis of patients with CNS infections and a recent travel history to endemic areas.
KW - Enterovirus
KW - Herpes simplex virus
KW - Meningoencephalitis
KW - Toscana virus
KW - West Nile virus
UR - http://www.scopus.com/inward/record.url?scp=84866405075&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84866405075&partnerID=8YFLogxK
U2 - 10.1016/j.jcv.2012.07.007
DO - 10.1016/j.jcv.2012.07.007
M3 - Article
C2 - 22867730
AN - SCOPUS:84866405075
SN - 1386-6532
VL - 55
SP - 204
EP - 208
JO - Journal of Clinical Virology
JF - Journal of Clinical Virology
IS - 3
ER -