Toluene and telencephalic dopamine: Selective reduction of amine turnover in discrete da nerve terminal systems of the anterior caudate nucleus by low concentrations of toluene

Kjell Fuxe, Kurt Andersson, Odd G. Nilsen, Rune Toftgård, Peter Eneroth, Jan-Ake Gustafsson

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

The present study demonstrates reductions of dopamine (DA) turnover in various areas of the anterior nucleus caudate of rat by toluene at concentrations lower than the current OSHA threshold limit value (100 ppm). Thus, toluene at low concentrations may produce disturbances in dopaminergic mechanisms of the basal ganglia probably leading to functional changes in sensory-motor integration. The increases in DA turnover in the cholecystokinin (CCK)-DA terminals of the subcortical limbic system induced by high concentrations of toluene may be part of the neurochemical basis for its abuse as a euphoric agent in man.

Original languageEnglish (US)
Pages (from-to)115-123
Number of pages9
JournalToxicology Letters
Volume12
Issue number2-3
DOIs
StatePublished - Jan 1 1982

ASJC Scopus subject areas

  • Toxicology

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