Abstract
The present study demonstrates reductions of dopamine (DA) turnover in various areas of the anterior nucleus caudate of rat by toluene at concentrations lower than the current OSHA threshold limit value (100 ppm). Thus, toluene at low concentrations may produce disturbances in dopaminergic mechanisms of the basal ganglia probably leading to functional changes in sensory-motor integration. The increases in DA turnover in the cholecystokinin (CCK)-DA terminals of the subcortical limbic system induced by high concentrations of toluene may be part of the neurochemical basis for its abuse as a euphoric agent in man.
Original language | English (US) |
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Pages (from-to) | 115-123 |
Number of pages | 9 |
Journal | Toxicology Letters |
Volume | 12 |
Issue number | 2-3 |
DOIs | |
State | Published - Jul 1982 |
ASJC Scopus subject areas
- Toxicology