Toll-like receptors and prostate cancer

Shu Zhao, Yifan Zhang, Qingyuan Zhang, Fen Wang, Dekai Zhang

Research output: Contribution to journalReview articlepeer-review

45 Scopus citations

Abstract

Prostate cancer is the second leading cause of cancer-related death in men after lung cancer. Immune responses clearly play a critical role in the tumorigenesis and in the efficacy of radiation therapy and chemotherapy in prostate cancer; however, the underlying molecular mechanisms are still poorly understood. Toll-like receptors (TLRs) are a well-known family of pattern recognition receptors that play a key role in host immune system. Recent studies demonstrate that there are links between TLRs and cancer; however, the function and biological importance of TLRs in prostate cancer seems complex. To elucidate the role of TLRs and innate immunity in prostate cancer might provide us with a better understanding of the molecular mechanisms of this disease. Moreover, utilizing the agonists or antagonists of TLRs might represent a promising new strategy against prostate cancer. In this review, we summarize recent advances on the studies of association between TLR signaling and prostate cancer, TLR polymorphisms and prostate cancer risk, and provide some insights about TLRs as potential targets for prostate cancer immunotherapy.

Original languageEnglish (US)
Article numberArticle 352
JournalFrontiers in immunology
Volume5
Issue numberJUL
DOIs
StatePublished - 2014

Keywords

  • Immunotherapy
  • Innate immunity
  • Prostate cancer
  • TLR signaling
  • Toll-like receptor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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