Titration of igg antibodies against varicella zoster virus before bone marrow transplantation is not predictive of future zoster

A. Webster, P. Grint, M. K. Brenner, H. G. Prentice, P. D. Griffiths

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Serum antibodies to varicella zoster virus (VZV) were measured in 77 patients about to undergo allogeneic bone marrow transplantation, and in 65 of their donors. Ten patients developed zoster within the first 6 months following transplant. There was no significant difference in the mean pretransplant antibody titre between those patients who did or did not subsequently develop zoster. Likewise, the level of antibody to VZV amongst donors had no effect on the subsequent development of zoster. We conclude that the pretransplant level of antibody to VZV is not predictive of subsequent zoster infection, and would not be helpful in identifying patients for trials of antiviral prophylaxis. These results contrast with those previously found for another herpesvirus, herpes simplex (HSV), where antibody level pretransplant is predictive of future HSV recurrence.

Original languageEnglish (US)
Pages (from-to)117-119
Number of pages3
JournalJournal of Medical Virology
Volume27
Issue number2
DOIs
StatePublished - Feb 1989

Keywords

  • IgG titration
  • VZV
  • herpesvirus

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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