Tissue specific opsonins for phagocytic cells and their different affinity for cholesterol-rich liposomes

S. Moein Moghimi, Harish M. Patel

Research output: Contribution to journalArticle

120 Scopus citations

Abstract

In accordance with the finding of our in vivo experiments reported earlier [(1983) Biochim. Biophys. Acta 761, 142-157 (1986) Biochim. Biophys. Acta 888, 184-190], the results of in vitro experiments show that Kupffer cells avidly take up cholesterol-poor but not cholesterol-rich liposomes, whereas splenic phagocytic cells take up preferentially cholesterol-rich rather than cholesterol-poor liposomes in the presence of serum. Evidence presented here suggests that serum contains opsonins specific for hepatic and splenic phagocytic cells and these opsonins have different affinities for cholesterol-rich and cholesterol-poor liposomes.

Original languageEnglish
Pages (from-to)143-147
Number of pages5
JournalFEBS Letters
Volume233
Issue number1
StatePublished - Jun 6 1988

Keywords

  • Cholesterol
  • Liposome (Liver, Spleen)
  • Macrophage
  • Opsonin

ASJC Scopus subject areas

  • Molecular Biology
  • Biophysics
  • Biochemistry

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