Tissue macroarray: A simple and cost-effective method for high-throughput studies

Liang Wang, Michael T. Deavers, Anais Malpica, Elvio G. Silva, Jinsong Liu

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The tissue microarray technique is a powerful technique that can examine many clinical specimens in a single slide. However, this technique requires a specialized instrument for the construction of tissue microarray block. The authors describe an alternative tissue macroarray technique for the simultaneous analysis of multiple clinical specimens on a single slide. As an example of this method, the authors assembled 12 tumor samples from 12 different paraffin blocks on a glass slide and then immunostained with hMLH1 antibody. This simple method does not need specialized equipment and should be an alternative efficient approach for large-scale clinical specimens.

Original languageEnglish (US)
Pages (from-to)174-176
Number of pages3
JournalApplied Immunohistochemistry and Molecular Morphology
Volume11
Issue number2
DOIs
StatePublished - Jun 2003

Keywords

  • Immunohistochemistry
  • Paraffin block
  • Tissue macroarray technique

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Medical Laboratory Technology

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