Tissue engineering advances in spine surgery

Melvin C. Makhni; Jon Michael E. Caldwell; Comron Saifi; Charla R. Fischer; Ronald A. Lehman; Lawrence G. Lenke; Francis Y. Lee

doi:10.2217/rme.16.3

Tissue engineering advances in spine surgery

Melvin C. Makhni, Jon Michael E. Caldwell, Comron Saifi, Charla R. Fischer, Ronald A. Lehman, Lawrence G. Lenke, Francis Y. Lee

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

Autograft, while currently the gold standard for bone grafting, has several significant disadvantages including limited supply, donor site pain, hematoma formation, nerve and vascular injury, and fracture. Bone allografts have their own disadvantages including reduced osteoinductive capability, lack of osteoprogenitor cells, immunogenicity and risk of disease transmission. Thus demand exists for tissue-engineered constructs that can produce viable bone while avoiding the complications associated with human tissue grafts. This review will focus on recent advancements in tissue-engineered bone graft substitutes utilizing nanoscale technology in spine surgery applications. An evaluation will be performed of bone graft substitutes, biomimetic 3D scaffolds, bone morphogenetic protein, mesenchymal stem cells and intervertebral disc regeneration strategies.

Original language	English (US)
Pages (from-to)	211-222
Number of pages	12
Journal	Regenerative Medicine
Volume	11
Issue number	2
DOIs	https://doi.org/10.2217/rme.16.3
State	Published - Mar 2016

Keywords

biomimetic
bone graft
bone morphogenetic protein
disc regeneration
scaffolds
spine
stem cells
surgery
tissue engineering

ASJC Scopus subject areas

Biomedical Engineering
Embryology

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10.2217/rme.16.3

Cite this

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title = "Tissue engineering advances in spine surgery",

abstract = "Autograft, while currently the gold standard for bone grafting, has several significant disadvantages including limited supply, donor site pain, hematoma formation, nerve and vascular injury, and fracture. Bone allografts have their own disadvantages including reduced osteoinductive capability, lack of osteoprogenitor cells, immunogenicity and risk of disease transmission. Thus demand exists for tissue-engineered constructs that can produce viable bone while avoiding the complications associated with human tissue grafts. This review will focus on recent advancements in tissue-engineered bone graft substitutes utilizing nanoscale technology in spine surgery applications. An evaluation will be performed of bone graft substitutes, biomimetic 3D scaffolds, bone morphogenetic protein, mesenchymal stem cells and intervertebral disc regeneration strategies.",

keywords = "biomimetic, bone graft, bone morphogenetic protein, disc regeneration, scaffolds, spine, stem cells, surgery, tissue engineering",

author = "Makhni, {Melvin C.} and Caldwell, {Jon Michael E.} and Comron Saifi and Fischer, {Charla R.} and Lehman, {Ronald A.} and Lenke, {Lawrence G.} and Lee, {Francis Y.}",

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AU - Makhni, Melvin C.

AU - Caldwell, Jon Michael E.

AU - Saifi, Comron

AU - Fischer, Charla R.

AU - Lehman, Ronald A.

AU - Lenke, Lawrence G.

AU - Lee, Francis Y.

PY - 2016/3

Y1 - 2016/3

N2 - Autograft, while currently the gold standard for bone grafting, has several significant disadvantages including limited supply, donor site pain, hematoma formation, nerve and vascular injury, and fracture. Bone allografts have their own disadvantages including reduced osteoinductive capability, lack of osteoprogenitor cells, immunogenicity and risk of disease transmission. Thus demand exists for tissue-engineered constructs that can produce viable bone while avoiding the complications associated with human tissue grafts. This review will focus on recent advancements in tissue-engineered bone graft substitutes utilizing nanoscale technology in spine surgery applications. An evaluation will be performed of bone graft substitutes, biomimetic 3D scaffolds, bone morphogenetic protein, mesenchymal stem cells and intervertebral disc regeneration strategies.

AB - Autograft, while currently the gold standard for bone grafting, has several significant disadvantages including limited supply, donor site pain, hematoma formation, nerve and vascular injury, and fracture. Bone allografts have their own disadvantages including reduced osteoinductive capability, lack of osteoprogenitor cells, immunogenicity and risk of disease transmission. Thus demand exists for tissue-engineered constructs that can produce viable bone while avoiding the complications associated with human tissue grafts. This review will focus on recent advancements in tissue-engineered bone graft substitutes utilizing nanoscale technology in spine surgery applications. An evaluation will be performed of bone graft substitutes, biomimetic 3D scaffolds, bone morphogenetic protein, mesenchymal stem cells and intervertebral disc regeneration strategies.

KW - biomimetic

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KW - scaffolds

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KW - stem cells

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KW - tissue engineering

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Tissue engineering advances in spine surgery

Abstract

Keywords

ASJC Scopus subject areas

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