Tip-to-Base LAMPOON for Transcatheter Mitral Valve Replacement With a Protected Mitral Annulus

John C. Lisko, Vasilis C. Babaliaros, Jaffar M. Khan, Norihiko Kamioka, Patrick T. Gleason, Gaetano Paone, Isida Byku, Jasleen Tiwana, James M. McCabe, Krishna Cherukuri, Ramzi Khalil, David Lasorda, Sachin S. Goel, Neal S. Kleiman, Michael J. Reardon, David V. Daniels, Christian Spies, Paul Mahoney, Brian C. Case, Brian K. WhisenantPradeep K. Yadav, Jose F. Condado, Rachel Koch, Kendra J. Grubb, Christopher G. Bruce, Toby Rogers, Robert J. Lederman, Adam B. Greenbaum

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Objectives: The purpose of this study was to evaluate tip-to-base intentional laceration of the anterior mitral leaflet to prevent left ventricular outflow tract obstruction (LAMPOON) in patients undergoing transcatheter mitral valve replacement (TMVR) in annuloplasty rings or surgical mitral valves. Background: LAMPOON is an effective adjunct to TMVR that prevents left ventricular outflow tract obstruction (LVOTO). Laceration is typically performed from the base to the tip of the anterior mitral leaflet. A modified laceration technique from leaflet tip to base may be effective in patients with a prosthesis that protects the aortomitral curtain. Methods: This is a multicenter, 21-patient, consecutive retrospective observational cohort. Patients underwent tip-to-base LAMPOON to prevent LVOTO and leaflet overhang, or therapeutically to lacerate a long anterior mitral leaflet risking or causing LVOTO. Outcomes were compared with findings from patients in the LAMPOON investigational device exemption trial with a prior mitral annuloplasty. Results: Twenty-one patients with a annuloplasty or valve prosthesis–protected mitral annulus underwent tip-to-base LAMPOON (19 preventive, 2 rescue). Leaflet laceration was successful in all and successfully prevented or treated LVOTO in all patients. No patients had significant LVOTO upon discharge. There were 2 cases of unintentional aortic valve injury (1 patient underwent emergency transcatheter aortic valve replacement and 1 patient underwent urgent surgical aortic valve replacement). In both cases, the patients had a supra-annular ring annuloplasty, and the retrograde aortic guiding catheter failed to insulate the guidewire lacerating surface from the aortic root. All patients survived to 30 days. Compared with classic retrograde LAMPOON, there was a trend toward shorter procedure time. Conclusions: Tip-to-base laceration is a simple, effective, and safe LAMPOON variant applicable to patients with an appropriately positioned mitral annular ring or bioprosthetic valve. Operators should take care to insulate the lacerating surface from adjacent structures.

Original languageEnglish (US)
Pages (from-to)541-550
Number of pages10
JournalJACC: Cardiovascular Interventions
Issue number5
StatePublished - Mar 8 2021


  • left ventricular outflow tract obstruction
  • mitral annuloplasty
  • mitral regurgitation
  • mitral stenosis
  • surgical mitral valve replacement
  • transcatheter electrosurgery
  • transcatheter mitral valve replacement

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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