Tiny But Mighty: Promising Roles of MicroRNAs in the Diagnosis and Treatment of Parkinson’s Disease

Ying Wang, Zhaofei Yang, Weidong Le

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Parkinson’s disease (PD) is the second most common age-related neurodegenerative disorder after Alzheimer’s disease. To date, the clinical diagnosis of PD is primarily based on the late onset of motor impairments. Unfortunately, at this stage, most of the dopaminergic neurons may have already been lost, leading to the limited clinical benefits of current therapeutics. Therefore, early identification of PD, especially at the prodromal stage, is still a main challenge in the diagnosis and management of this disease. Recently, microRNAs (miRNAs) in cerebrospinal fluid or peripheral blood have been proposed as putative biomarkers to assist in PD diagnosis and therapy. In this review, we systematically summarize the changes of miRNA expression profiles in PD patients, and highlight their putative roles in the diagnosis and treatment of this devastating disease.

Original languageEnglish (US)
Pages (from-to)543-551
Number of pages9
JournalNeuroscience Bulletin
Volume33
Issue number5
DOIs
StatePublished - Oct 1 2017

Keywords

  • Biomarker
  • Diagnosis
  • MicroRNA
  • Parkinson’s disease

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

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