TY - JOUR
T1 - Tiny But Mighty
T2 - Promising Roles of MicroRNAs in the Diagnosis and Treatment of Parkinson’s Disease
AU - Wang, Ying
AU - Yang, Zhaofei
AU - Le, Weidong
N1 - Funding Information:
This review was supported by the National Natural Science Foundation of China (81430021 and 81370470).
Publisher Copyright:
© 2017, Shanghai Institutes for Biological Sciences, CAS and Springer Nature Singapore Pte Ltd.
PY - 2017/10/1
Y1 - 2017/10/1
N2 - Parkinson’s disease (PD) is the second most common age-related neurodegenerative disorder after Alzheimer’s disease. To date, the clinical diagnosis of PD is primarily based on the late onset of motor impairments. Unfortunately, at this stage, most of the dopaminergic neurons may have already been lost, leading to the limited clinical benefits of current therapeutics. Therefore, early identification of PD, especially at the prodromal stage, is still a main challenge in the diagnosis and management of this disease. Recently, microRNAs (miRNAs) in cerebrospinal fluid or peripheral blood have been proposed as putative biomarkers to assist in PD diagnosis and therapy. In this review, we systematically summarize the changes of miRNA expression profiles in PD patients, and highlight their putative roles in the diagnosis and treatment of this devastating disease.
AB - Parkinson’s disease (PD) is the second most common age-related neurodegenerative disorder after Alzheimer’s disease. To date, the clinical diagnosis of PD is primarily based on the late onset of motor impairments. Unfortunately, at this stage, most of the dopaminergic neurons may have already been lost, leading to the limited clinical benefits of current therapeutics. Therefore, early identification of PD, especially at the prodromal stage, is still a main challenge in the diagnosis and management of this disease. Recently, microRNAs (miRNAs) in cerebrospinal fluid or peripheral blood have been proposed as putative biomarkers to assist in PD diagnosis and therapy. In this review, we systematically summarize the changes of miRNA expression profiles in PD patients, and highlight their putative roles in the diagnosis and treatment of this devastating disease.
KW - Biomarker
KW - Diagnosis
KW - MicroRNA
KW - Parkinson’s disease
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U2 - 10.1007/s12264-017-0160-z
DO - 10.1007/s12264-017-0160-z
M3 - Review article
C2 - 28762215
AN - SCOPUS:85026542917
SN - 1673-7067
VL - 33
SP - 543
EP - 551
JO - Neuroscience Bulletin
JF - Neuroscience Bulletin
IS - 5
ER -