Time trends of delirium rates in the intensive care unit

Sikandar H. Khan, Heidi Lindroth, Kyle Hendrie, Sophia Wang, Sundus Imran, Anthony J. Perkins, Sujuan Gao, Farhaan S. Vahidy, Malaz Boustani, Babar A. Khan

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Background: Effects of clinical practice changes on ICU delirium are not well understood. Objectives: Determine ICU delirium rates over time. Methods: Data from a previously described screening cohort of the Pharmacological Management of Delirium trial was analyzed. Richmond Agitation-Sedation Scale (RASS) and Confusion Assessment Method for the ICU (CAM-ICU) were assessed twice daily. We defined: Any delirium (positive CAM-ICU at any time during ICU stay) and ICU-acquired delirium (1st CAM-ICU negative with a subsequent positive CAM-ICU). Mixed-effects logistic regression models were used to test for differences. Results: 2742 patient admissions were included. Delirium occurred in 16.5%, any delirium decreased [22.7% to 10.2% (p < 0.01)], and ICU-acquired delirium decreased [8.4% to 4.4% (p = 0.01)]. Coma decreased from 24% to 17.4% (p = 0.04). Later ICU years and higher mean RASS scores were associated with lower odds of delirium. Conclusions: Delirium rates were not explained by the measured variables and further prospective research is needed.

Original languageEnglish (US)
Pages (from-to)572-577
Number of pages6
JournalHeart and Lung
Issue number5
StatePublished - Sep 1 2020


  • Delirium
  • Intensive care unit
  • Outcomes
  • Time trend

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine


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