Time Trends in Major Adverse Cardiovascular Events After Percutaneous Coronary Intervention: Meta-Analysis on Sex Differences

Shayan Shojaei, Asma Mousavi, Hamidreza Soleimani, Fatemeh Takaloo, Peyvand Parhizkar Roudsari, Dorsa Salabat, Amirreza Shahmohamady, Mehdi Mehrani, Parisa Seilani, Haleh Ashraf, John Nelson, Rosy Thachil, Fady Iskander, Safi U. Khan, Nasir Khurram, Kaveh Hosseini

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Percutaneous coronary intervention (PCI) is considered the procedure of choice for patients with acute coronary syndrome (ACS), as it significantly improves cardiovascular outcomes. However, considerable uncertainty persists regarding the potential sex differences in PCI outcomes, due to conflicting results in previous studies. Objectives: This meta-analysis aims to evaluate potential sex-related differences in cardiovascular adverse outcomes after PCI among ACS patients. Methods: The primary outcome was major adverse cardiovascular events (MACE) and its components. Outcomes were examined in various time frames including: short-term (within 1 month after PCI), mid-term (within 1 year), and long-term (within >1 year). A random effects model was used to estimate risk ratios (RR) and 95% CIs. Results: Among 32 trials, at short-term, PCI was associated with a higher risk of MACE (risk ratio [RR]: 1.43; 95% CI: 1.10-1.86), all-cause mortality (RR: 2.51; 95% CI: 1.70-3.71), and myocardial infarction (RR: 1.33; 95% CI: 1.00-1.77) in women compared with men. Over the long-term, women had a higher risk of MACE (RR: 1.11; 95% CI: 1.01-1.22), all-cause mortality (RR: 1.29; 95% CI: 1.17-1.42), and cardiovascular mortality (RR: 1.30; 95% CI: 1.11-1.52), when compared with men. However, the analysis for stroke and repeat revascularization showed no significant difference between the 2 groups in the long- and short-term. Conclusions: In the meta-analysis of PCI-related trials in ACS, women have a higher risk of adverse cardiovascular outcomes compared with men.

Original languageEnglish (US)
Article number101526
JournalJACC: Advances
Volume4
Issue number2
DOIs
StatePublished - Feb 2025

Keywords

  • acute coronary syndrome
  • major adverse cardiovascular events
  • percutaneous coronary intervention
  • sex differences

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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