Time-dependent alterations in functional and pharmacological arteriolar reactivity after subarachnoid hemorrhage

Gavin W. Britz, Joseph R. Meno, Ik Seong Park, Taylor J. Abel, Abhineet Chowdhary, Thien Son K. Nguyen, H. Richard Winn, Al C. Ngai

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

BACKGROUND AND PURPOSE - Disturbances in cerebral arteriolar function, in addition to large vessel vasospasm, may be responsible for ischemia after subarachnoid hemorrhage. The purpose of this study was to test the hypothesis that subarachnoid hemorrhage alters cerebral microvascular reactivity. METHODS - An endovascular filament model was used to induce subarachnoid hemorrhage in halothane-anesthetized male Sprague-Dawley rats. We evaluated pial arteriolar responses to sciatic nerve stimulation, topically applied vasoactive agents (adenosine or sodium nitroprusside), and CO2 inhalation in rats subjected to subarachnoid hemorrhage at 1 to 5 days after insult. RESULTS - In sham-operated rats, sciatic nerve stimulation evoked a 23.5±1.8% increase in arteriolar diameter, which was significantly attenuated to 13.7±0.9%, 12.8±2.5%, and 18.8±2.9% at 24, 48, and 72 hours after subarachnoid hemorrhage, respectively (P<0.05; n=7). At 96 and 120 hours after subarachnoid hemorrhage, sciatic nerve stimulation-induced dilation recovered to sham levels. Somatosensory-evoked potentials were unaltered by subarachnoid hemorrhage. Pial vasodilatation to adenosine (10 μmol/L) and sodium nitroprusside (1 μmol/L) were significantly impaired, by 47% and 41%, respectively, at 48 hours after subarachnoid hemorrhage (P<0.05; n=7). In contrast, CO2 reactivity was unaffected by subarachnoid hemorrhage. CONCLUSIONS - Pial arteriolar responses to cortical activation may be decreased in the initial 2 to 3 days after experimental subarachnoid hemorrhage.

Original languageEnglish (US)
Pages (from-to)1329-1335
Number of pages7
JournalStroke
Volume38
Issue number4
DOIs
StatePublished - Apr 2007

Keywords

  • Cerebral arterioles
  • Somatosensory stimulation
  • Subarachnoid hemorrhage

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)
  • Medicine(all)

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