Time course for autoregulation recovery following severe traumatic brain injury: Clinical article

Gill E. Sviri, Rune Aaslid, Colleen M. Douville, Anne Moore, David W. Newell

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

Object. The aim of the present study was to evaluate the time course for cerebral autoregulation (AR) recovery following severe traumatic brain injury (TBI) Methods. Thirty-six patients (27 males and 9 females, mean ± SEM age 33 ± 15.1 years) with severe TBI underwent serial dynamic AR studies with leg cuff deflation as a stimulus, until recovery of the AR responses was measured. Results. The AR was impaired (AR index < 2.8) in 30 (83%) of 36 patients on Days 3-5 after injury, and in 19 individuals (53%) impairments were found on Days 9-11 after the injury. Nine (25%) of 36 patients exhibited a poor AR response (AR index < 1) on postinjury Days 12-14, which eventually recovered on Days 15-23. Fifty-eight percent of the patients with a Glasgow Coma Scale score of 3-5, 50% of those with diffuse brain injury, 54% of those with elevated intracranial pressure, and 40% of those with poor outcome had no AR recovery in the first 11 days after injury. Conclusions. Autoregulation recovery after severe TBI can be delayed, and failure to recover during the 2nd week after injury occurs mainly in patients with a lower Glasgow Coma Scale score, diffuse brain injury, elevated ICP, or unfavorable outcome. The finding suggests that perfusion pressure management should be considered in some of the patients for a period of at least 2 weeks.

Original languageEnglish (US)
Pages (from-to)695-700
Number of pages6
JournalJournal of Neurosurgery
Volume111
Issue number4
DOIs
StatePublished - 2009

Keywords

  • Autoregulation
  • Blood flow
  • Brain injury
  • Outcome
  • Transcranial Doppler ultrasound

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

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